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Tocilizumab in pediatric refractory status epilepticus and acute epilepsy: Experience in two patients.

07:00 EST 3rd January 2020 | BioPortfolio

Summary of "Tocilizumab in pediatric refractory status epilepticus and acute epilepsy: Experience in two patients."

There is growing evidence for inflammation as a cause and/or consequence of seizures in epilepsy as certain inflammatory biomarkers are elevated. Interleukin (IL)-6, with pro-inflammatory and epileptogenic effects, can perpetuate seizures. Clinical and experimental data support its involvement in acute refractory situations, with some cases responding to treatment with tocilizumab, a humanized monoclonal antibody against the IL-6 receptor. We describe 2 pediatric cases of refractory epilepsy with an abrupt debut responding to tocilizumab. Advances in the knowledge of inflammatory biomarkers involved in epilepsy and the targeted treatment could have important benefits, especially in cases that are refractory to usual treatments.

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This article was published in the following journal.

Name: Journal of neuroimmunology
ISSN: 1872-8421
Pages: 577142

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