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Cytotoxic sesquiterpene glucosides from Fissistigma pallens.

07:00 EST 11th January 2020 | BioPortfolio

Summary of "Cytotoxic sesquiterpene glucosides from Fissistigma pallens."

Six undescribed sesquiterpene glucosides, fissispallins A-F, and one known sesquiterpene glucoside, fissispallin, were discovered in the leaves of Fissistigma pallens (Finet & Gagnep.) Merr. The structures were determined using spectroscopic methods, including 1D, 2D NMR, and MS. All compounds were evaluated for cytotoxic activity against three human cancer cell lines, HT-29, A-2058, and A-549. Fissispallin A showed potent activity with the IC values less than 1.5 μM against all tested human cancer cell lines. Fissispallin also showed potent activity with IC value of 0.4 ± 0.3 on the A-2058 cancer cell lines. Fissispallins B-D showed significant cytotoxic activity against all the tested cancer cell lines with IC values ranging from 3.8 to 7.2 μM.

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This article was published in the following journal.

Name: Phytochemistry
ISSN: 1873-3700
Pages: 112255

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Medical and Biotech [MESH] Definitions

A plant genus of the family SCROPHULARIACEAE. Members contain bis-sesquiterpene and iridoid glucosides.

A plant genus of the family ASTERACEAE. Sesquiterpene lactone glucosides (SESQUITERPENES) have been found in it.

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