Cytotoxic sesquiterpene glucosides from Fissistigma pallens.

07:00 EST 11th January 2020 | BioPortfolio

Summary of "Cytotoxic sesquiterpene glucosides from Fissistigma pallens."

Six undescribed sesquiterpene glucosides, fissispallins A-F, and one known sesquiterpene glucoside, fissispallin, were discovered in the leaves of Fissistigma pallens (Finet & Gagnep.) Merr. The structures were determined using spectroscopic methods, including 1D, 2D NMR, and MS. All compounds were evaluated for cytotoxic activity against three human cancer cell lines, HT-29, A-2058, and A-549. Fissispallin A showed potent activity with the IC values less than 1.5 μM against all tested human cancer cell lines. Fissispallin also showed potent activity with IC value of 0.4 ± 0.3 on the A-2058 cancer cell lines. Fissispallins B-D showed significant cytotoxic activity against all the tested cancer cell lines with IC values ranging from 3.8 to 7.2 μM.


Journal Details

This article was published in the following journal.

Name: Phytochemistry
ISSN: 1873-3700
Pages: 112255


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A plant genus of the family SCROPHULARIACEAE. Members contain bis-sesquiterpene and iridoid glucosides.

A plant genus of the family ASTERACEAE. Sesquiterpene lactone glucosides (SESQUITERPENES) have been found in it.

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