Coumarin and spirocyclopentenone derivatives from the leaves and stems of Murraya paniculata (L.) Jack.

07:00 EST 11th January 2020 | BioPortfolio

Summary of "Coumarin and spirocyclopentenone derivatives from the leaves and stems of Murraya paniculata (L.) Jack."

Seven previously undescribed compounds, including five coumarins, (+/-)-murpanitin A and murpanitins B-D, and a pair of spirocyclopentenone enantiomers, (+/-)-murrayaspiroketone, along with 14 known coumarin derivatives were isolated from the leaves and stems of Murraya paniculata (L.) Jack. Their structures were elucidated on the basis of comprehensive analysis of 1D and 2D NMR and HRMS spectroscopic data, and the absolute configurations were assigned via calculated and experimental ECD data. Three compounds showed moderate inhibitory effects on nitric oxide production stimulated by lipopolysaccharide in BV-2 microglial cells with IC values of 53.2 ± 8.9, 57.7 ± 5.8, and 53.2 ± 4.4 μM, respectively.


Journal Details

This article was published in the following journal.

Name: Phytochemistry
ISSN: 1873-3700
Pages: 112258


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