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The present work describes coordination chemistry and biological evaluation of two novel dinuclear complexes [Co(HL)(HO)]·8HO (1) and [Cu(L)] (2) obtained from the Schiff base ligands, HL and HL (formed in situ). The two complexes are characterized by single crystal X-ray, spectral and variable temperature magnetic and theoretical (DFT/TDDFT) analysis. X-ray analysis confirms both the complexes to be dinuclear with distorted octahedral and square pyramidal geometry around Co(II) and Cu(II) ions, respectively. Magnetic studies reveal presence of moderate ferromagnetic interactions in both the complexes with J = 98 (1) and 32 (2) cm. The magnetic interactions are further corroborated by DFT studies. Co(II) complex (1) exhibited enhanced catecholase activity with K = 213.48 h, which is attributed to the greater extent of charge contribution on Co as compared to Cu as determined by DFT calculations. Furthermore, both the complexes show potent anticancer activity toward HeLa (cervical) and A549 (lung) cancer cell lines with IC = 6-7 µM at 48 h, which ascertains both the complexes as better anticancer drugs than cisplatin. Furthermore, 1 and 2 exhibit apoptosis of HeLa cells by demonstrating nuclear blebbings with shrinking morphology. Hence, the present complexes could be employed as a model for metalloenzymes as well as potential anticancer substituents of cisplatin in future course.
This article was published in the following journal.
Name: Bioorganic chemistry
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Stable cobalt atoms that have the same atomic number as the element cobalt, but differ in atomic weight. Co-59 is a stable cobalt isotope.
Unstable isotopes of cobalt that decay or disintegrate emitting radiation. Co atoms with atomic weights of 54-64, except 59, are radioactive cobalt isotopes.
Specific alloys not less than 85% chromium and nickel or cobalt, with traces of either nickel or cobalt, molybdenum, and other substances. They are used in partial dentures, orthopedic implants, etc.
Biological properties, processes, and activities of VIRUSES.
Synthetic compounds that are analogs of the naturally occurring prostaglandin endoperoxides and that mimic their pharmacologic and physiologic activities. They are usually more stable than the naturally occurring compounds.
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