Topics

Anticancer properties, apoptosis and catecholase mimic activities of dinuclear cobalt(II) and copper(II) Schiff base complexes.

07:00 EST 29th December 2019 | BioPortfolio

Summary of "Anticancer properties, apoptosis and catecholase mimic activities of dinuclear cobalt(II) and copper(II) Schiff base complexes."

The present work describes coordination chemistry and biological evaluation of two novel dinuclear complexes [Co(HL)(HO)]·8HO (1) and [Cu(L)] (2) obtained from the Schiff base ligands, HL and HL (formed in situ). The two complexes are characterized by single crystal X-ray, spectral and variable temperature magnetic and theoretical (DFT/TDDFT) analysis. X-ray analysis confirms both the complexes to be dinuclear with distorted octahedral and square pyramidal geometry around Co(II) and Cu(II) ions, respectively. Magnetic studies reveal presence of moderate ferromagnetic interactions in both the complexes with J = 98 (1) and 32 (2) cm. The magnetic interactions are further corroborated by DFT studies. Co(II) complex (1) exhibited enhanced catecholase activity with K = 213.48 h, which is attributed to the greater extent of charge contribution on Co as compared to Cu as determined by DFT calculations. Furthermore, both the complexes show potent anticancer activity toward HeLa (cervical) and A549 (lung) cancer cell lines with IC = 6-7 µM at 48 h, which ascertains both the complexes as better anticancer drugs than cisplatin. Furthermore, 1 and 2 exhibit apoptosis of HeLa cells by demonstrating nuclear blebbings with shrinking morphology. Hence, the present complexes could be employed as a model for metalloenzymes as well as potential anticancer substituents of cisplatin in future course.

Affiliation

Journal Details

This article was published in the following journal.

Name: Bioorganic chemistry
ISSN: 1090-2120
Pages: 103561

Links

DeepDyve research library

PubMed Articles [15072 Associated PubMed Articles listed on BioPortfolio]

Facile synthesis of a new Cu(ii) complex with an unsymmetrical ligand and its use as an O donor metalloligand in the synthesis of Cu(ii)-Mn(ii) complexes: structures, magnetic properties, and catalytic oxidase activities.

A new, facile Cu(ii) template method has been employed for the unsymmetrical dicondensation of 1,2-ethylenediamine with salicylaldehyde and o-vanillin. The mononuclear complex, [CuL] (1), thus obtaine...

Berbamine exerts anticancer effects on human colon cancer cells via induction of autophagy and apoptosis, inhibition of cell migration and MEK/ERK signalling pathway.

Berbamine is a plant-derived alkaloid with amazing and wide diversity of pharmacological properties which range from antimicrobial and anticancer. Nonetheless, the anticancer properties of Berbamine h...

Rhodium(iii) complexes with isoquinoline derivatives as potential anticancer agents: in vitro and in vivo activity studies.

Two rhodium complexes Rh1 and Rh2 with isoquinoline derivatives were synthesized and characterized. Both complexes displayed strong anticancer activity against various cancer cells and low cytotoxicit...

Potential anticancer agent for selective damage to mitochondria or lysosomes: Naphthalimide-modified fluorescent biomarker half-sandwich iridium (III) and ruthenium (II) complexes.

In this work, five naphthalimide-modified half-sandwich iridium and ruthenium complexes ([(η-Cp)Ir(NˆN)Cl]PF, [(η-p-cym)Ru(NˆN)Cl]PF) have been presented. The anticancer activities of the complexe...

Design, Synthesis, and Structure-Activity Relationship of 7-Propanamide Benzoxaboroles as Potent Anticancer Agents.

Benzoxaboroles, as a novel class of bioactive molecules with unique physicochemical properties, have been shown to possess excellent antimicrobial activities with tavaborole approved in 2014 as an ant...

Clinical Trials [3434 Associated Clinical Trials listed on BioPortfolio]

Comparison Between Injection Molded PEEK Framework and Cobalt Chromium Framework in Removable Partial Denture Regarding Retention

This study is aiming to evaluate the retentive forces in PEEK framework RPD compared to Cobalt-Chrome framework RPD during attachment/detachment cycles in mandibular kennedy class I edentu...

A Comparison Between Titanium Femoral Stem and Cobalt-Chromium Femoral Stem in Cemented Hip Arthroplasty

In this randomised study, the migration of a specific cemented titanium femoral stem will be compared with a similar cemented cobalt-chromium stem using Roentgen stereogrammetric analysis ...

The ACTIVE (Use of the Assurant® Cobalt Iliac Stent System in the Treatment of Iliac Vessel Disease) Study

The objective of this study is to evaluate the safety and efficacy of the Assurant Cobalt Iliac Stent System in the treatment of de novo and restenotic lesions in iliac arteries of subject...

Study to Evaluate the Safety of Cronus® - Cobalt Chromium Coronary Stent

The objective this study is evaluate the performance and safety of Chronus® cobalt-chromium coronary stent in patients with "de novo" native coronary artery lesions treated with 19-mm-lon...

Effects of Yangxinshi Pills on the Exercise Tolerance Compared With Trimetazidine in Patients After PCI

This study compared the effect of Yangxinshi on exercise tolerance of patients with percutaneous coronary intervention (PCI) for the first time with Trimetazidine.Half of participants will...

Medical and Biotech [MESH] Definitions

Stable cobalt atoms that have the same atomic number as the element cobalt, but differ in atomic weight. Co-59 is a stable cobalt isotope.

Unstable isotopes of cobalt that decay or disintegrate emitting radiation. Co atoms with atomic weights of 54-64, except 59, are radioactive cobalt isotopes.

Specific alloys not less than 85% chromium and nickel or cobalt, with traces of either nickel or cobalt, molybdenum, and other substances. They are used in partial dentures, orthopedic implants, etc.

Biological properties, processes, and activities of VIRUSES.

Synthetic compounds that are analogs of the naturally occurring prostaglandin endoperoxides and that mimic their pharmacologic and physiologic activities. They are usually more stable than the naturally occurring compounds.

Quick Search


DeepDyve research library

Relevant Topic

Biological Therapy
Biological therapy involves the use of living organisms, substances derived from living organisms, or laboratory-produced versions of such substances to treat disease. Some biological therapies for cancer use vaccines or bacteria to stimulate the body&rs...


Searches Linking to this Article