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Cathodic protected Mn by NaWO nanorods for stable magnetic resonance imaging-guided tumor photothermal therapy.

07:00 EST 8th January 2020 | BioPortfolio

Summary of "Cathodic protected Mn by NaWO nanorods for stable magnetic resonance imaging-guided tumor photothermal therapy."

The stability and safety of magnetic resonance imaging (MRI) contrast agents (CAs) are crucial for accurate diagnosis and real-time monitor of tumor development. Paramagnetic Mn as nonlanthanide metal ion has been widely studied for use in T-MRI CAs, but unfortunately, Mn can be oxidized by HO in tumor to nonparamagnetic Mn via a Fenton-like reaction. The concurrent loss of paramagnetism and production of toxic hydroxyl radical (OH) go against the basic requirment of CAs, thus restricting the further development of Mn-based CAs. Based on the different standard potential of W/W (~0.26 V) and Mn/Mn (~1.2 V), a "cathodic protection" strategy was exploited in Mn-doped NaWO nanorods (NaMnWO), with W as the sacrificial anode and Mn as the protected cathode, to protect Mn from oxidation in tumor for stable MR contrast performance, as well as repress its Fenton-like reaction activity for good biosafety. Moreover, the tungsten bronze crystal structure endows NaMnWO with excellent near-infrared (NIR)-photothermal properties for effective tumor hyperthermia, without effect from the changed oxidation state of W. This "cathodic protection" strategy offers a new method for the development of reliable and hypotoxic biomaterials for stable imaging and therapeutic applications in clinic.

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This article was published in the following journal.

Name: Biomaterials
ISSN: 1878-5905
Pages: 119762

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