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Boron nitride nanosheets (BN NSs), a novel material with a structure similar to graphene, have attracted much attention due to their extraordinary properties. A deep in vivo study of the toxicity of BN NSs is indispensable, which can help to understand their potential risk and provide useful information for their safe application. However, so far as we know, the systematic in vivo toxicity evaluation of BN NSs hasn't been reported. In this study, silkworm (Bombyx mori) was used as a model to investigate the toxicity of BN NSs, by continuously feeding silkworm larvae with BN NSs at various mass concentrations (1%, 2%, 3%, 4%). The toxicity was evaluated from the levels of animal entirety (mortality, silkworm growth, cocoons and silk properties), tissues (pathological examination) and genes (transcriptomic profiling). The results show that the exposure to BN NSs causes no obvious adverse effects on the growth, silk properties or tissues of silkworm, but the expressions of genes in midgut concerned with some specific functions and pathways are significantly changed, indicating that BN NSs may have potential danger to lead to dysfunction. This study has performed in vivo toxicity evaluation of BN NSs and provided useful safety information for the application of BN NSs.
This article was published in the following journal.
Bacillus thuringiensis Cry1Ai belongs to three-domain Cry toxins and only shows growth inhibition effects against the agricultural pest Helicoverpa armigera, although it exhibits high toxicity against...
Hexagonal boron nitride is a large band-gap insulating material which complements the electronic and optical properties of graphene and the transition metal dichalcogenides. However, the intrinsic opt...
Insulin family peptides are known to be key regulators of growth and metabolism in insects and vertebrates. Insects have two types of insulin family peptides: insulin-like peptides and insulin-like gr...
Hexagonal boron nitride (hBN) has displayed increased potentials in heat dissipation applications due to its desirable high thermal conductivity and remarkable thermal stability. However, the large-yi...
Boron nitride (BN) nanosheets hold great promise as emerging building blocks for advanced membranes owing to their superior stability and rigidity. Herein, we report a BN membrane with distinct nanoco...
RATIONALE: Boron neutron capture therapy may selectively kill tumor cells without harming normal tissue. PURPOSE: Phase II trial to study the effectiveness of boron neutron capture therap...
Boron Neutron Capture Therapy (BNCT) is an experimental radiation therapy technique that is based on the principle of irradiating boron atoms with neutrons. When neutrons have relatively l...
The purpose of the study is to investigate efficacy and safety boron neutron capture therapy (BNCT) administered in combination with cetuximab in the treatment of head and neck cancer that...
Boron Neutron Capture Therapy (BNCT) is an experimental radiation therapy technique which is based on the principle of irradiating boron atoms with neutrons. When neutrons have relatively ...
RATIONALE: Boron neutron capture therapy may selectively kill tumor cells without harming normal tissue. PURPOSE: This phase I trial is studying the side effects and best dose of boron ne...
A genus of silkworm MOTHS in the family Bombycidae of the order LEPIDOPTERA. The family contains a single species, Bombyx mori from the Greek for silkworm + mulberry tree (on which it feeds). A native of Asia, it is sometimes reared in this country. It has long been raised for its SILK and after centuries of domestication it probably does not exist in nature. It is used extensively in experimental GENETICS. (From Borror et al., An Introduction to the Study of Insects, 4th ed, p519)
Nanometer-sized tubes composed of various substances including carbon (CARBON NANOTUBES), boron nitride, or nickel vanadate.
A trace element with the atomic symbol B, atomic number 5, and atomic weight 10.81. Boron-10, an isotope of boron, is used as a neutron absorber in BORON NEUTRON CAPTURE THERAPY.
Fibrous proteins secreted by INSECTS and SPIDERS. Generally, the term refers to silkworm fibroin secreted by the silk gland cells of SILKWORMS, Bombyx mori. Spider fibroins are called spidroins or dragline silk fibroins
The homologous chromosomes that are dissimilar in the heterogametic sex. There are the X CHROMOSOME, the Y CHROMOSOME, and the W, Z chromosomes (in animals in which the female is the heterogametic sex (the silkworm moth Bombyx mori, for example)). In such cases the W chromosome is the female-determining and the male is ZZ. (From King & Stansfield, A Dictionary of Genetics, 4th ed)