Effects of PM exposure during gestation on maternal gut microbiota and pregnancy outcomes.

07:00 EST 9th January 2020 | BioPortfolio

Summary of "Effects of PM exposure during gestation on maternal gut microbiota and pregnancy outcomes."

A number of studies have reported that fine particulate matter (PM) exposure is associated with adverse pregnancy outcomes. Moreover, PM exposure contributes to changes of gut microbiota. However, influences of PM exposure during gestation on maternal gut microbiota and pregnancy outcomes were not well understood. Here we performed a study using mice models. Dams were exposed to PM suspension by intratracheal instillation on gestational day (GD) 3, 6, 9, 12 and 15. Pregnancy outcomes, maternal gut microbiota and short chain fatty acids on GD 18 were all measured. The fetal body weight of PM group was significantly lower than that of control group (p < 0.05). Meanwhile, the fetal body length of PM group was significantly shorter than that of control group (p < 0.05). The Shannon or Simpson index of PM group were higher than that of control group (p < 0.05). At the phyla level, compared to dams in control group, mice in the PM group had higher ratio of phyla Proteobacteria, Candidatus Saccharibacteria and Fusobacteria and lower ratio of phyla Acidobacteria, Gemmatimonadetes and Deferribacteres in the gut. Compared with control group, the concentration of isobutyric acid was higher in PM group, but butyric acid concentration was lower in PM group (p < 0.05). These findings suggested that prenatal exposure to PM had an effect on birth weight of fetus. Meanwhile, PM tracheal exposure during gestation caused changes in the distribution and structure of gut microbiota of dams.


Journal Details

This article was published in the following journal.

Name: Chemosphere
ISSN: 1879-1298
Pages: 125879


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