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PM-induced inflammation and lipidome alteration associated with the development of atherosclerosis based on a targeted lipidomic analysis.

07:00 EST 11th January 2020 | BioPortfolio

Summary of "PM-induced inflammation and lipidome alteration associated with the development of atherosclerosis based on a targeted lipidomic analysis."

Epidemiological studies have confirmed that PM could contribute to the development of atherosclerosis accompanied with lipids dysregulation. However, the lipids biomarkers involved in this progress remain largely unknown. In this study, a targeted lipidomic approach was used to find out the possible lipid biomarkers involved in the development of atherosclerosis after PM exposure or during a recovery period. Also, we assessed the pro-atherosclerosis effects of PM and follow-up influence using pulse wave (PW) Doppler ultrasound, oil red O staining and H&E staining. The vascular stiffness was elevated after 2-month PM exposure and might persist after 1-month recovery. While the lesions mostly concentrated in the aortic arch was significantly increased in 2-month PM exposure group and remained an increasing trend after 1-month recovery. The expressions of pro-inflammatory cytokines detected by Mouse Inflammation Array were elevated after ApoE mice treated with PM for 2-month and restored following 1-month recovery. Yet, IL-10 was significantly decreased during 1-month recovery. Additionally, the targeted lipidomic analysis demonstrated that cholesterol ester (CE), phosphatidylcholine (PC), phosphatidylethanolamine (PE), sphingomyelin (SM) were significantly increased while lysophosphatidylethanolamine (LPE), lysophosphatidylcholine (LPC), diacylglycerol (DG), triacylglycerol (TG) were reduced after 2-month PM exposure, indicating that PM could disrupt glycerophospholipids, glycerolipids and sphingolipids metabolism. And a persistent impact of PM on glycerophospholipids and glycerolipids metabolism was found after 1-month recovery. Our study demonstrated that PM-induced inflammation response might promote atherosclerotic lesions probably through lipid dysregulation, and the influence probably persisted after 1-month recovery.

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This article was published in the following journal.

Name: Environment international
ISSN: 1873-6750
Pages: 105444

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