Bioaccumulation, biodistribution,and depuration of C-labelled fullerenols in zebrafish through dietary exposure.

07:00 EST 11th January 2020 | BioPortfolio

Summary of "Bioaccumulation, biodistribution,and depuration of C-labelled fullerenols in zebrafish through dietary exposure."

In aquatic organisms, dietary exposure to nanomaterials is not only one of the important uptake pathways, but it is also one method to assess the transmission risk of the food chain. To address this concern, we quantitatively investigated the accumulation and depuration of fullerenols in the tissues of zebrafish after exposure to fullerenols-contaminated Daphnia magna. After exposure to C-labelled fullerenol solution at a concentration of 2.5 mg/L for 72 h, the steady state concentration of fullerenols in D. magna was 31.20 ± 1.59 mg/g dry weight. During the 28 d uptake period for zebrafish, fullerenols in the tissues increased in a tissue- and day-dependent manner, and the major target tissues of fullerenols were the intestines and liver, followed by the gill, muscle, and brain. The kinetic parameters of uptake and depuration were also quantitatively analyzed. After depuration for 15 d, a certain amount of residual fullerenols remained in the tissues, especially the brain, where approximately 64 d may be needed to achieve 90% of the cumulative concentration depuration. The calculated distribution-based trophic transfer factors (TTF values) (from 0.26 to 0.49) indicated that the tissue biomagnification of fullerenols by zebrafish through dietary exposure may not occur. Transmission electron microscopy (TEM) confirmed the presence of fullerenols in D. magna and the tissues of zebrafish. Our research data are essential for thoroughly understanding of the fate of nanoparticles through the dietary exposure pathway and directing future tissue bioeffect studies regarding target tissues for further research.


Journal Details

This article was published in the following journal.

Name: Ecotoxicology and environmental safety
ISSN: 1090-2414
Pages: 110173


DeepDyve research library

PubMed Articles [3128 Associated PubMed Articles listed on BioPortfolio]

Multi-compartmental toxicokinetic modeling of discrete dietary and continuous waterborne uptake of two polycyclic aromatic hydrocarbons by zebrafish Danio rerio.

In the present study, we developed a multi-compartmental toxicokinetic model for two polycyclic aromatic hydrocarbons (phenanthrene and anthracene) in their deuterated form (PAHs-d10) in zebrafish con...

Glutathione biosynthesis plays an important role in microcystin-LR depuration in lettuce and spinach.

Irrigation of crop plants with microcystins (MCs) contaminated water could be a threat to human health via bioaccumulation. Despite the fact MCs bioaccumulation in crop plants is well documented, MCs ...

A Toxicokinetic Framework and Analysis Tool for Interpreting OECD-305 Dietary Bioaccumulation Tests.

The OECD-305 guidelines for bioaccumulation testing in fish include the option to conduct a dietary test for assessing a chemical's bioaccumulation behavior. However, the one-compartment toxicokinetic...

Waterborne and dietary accumulation of well-dispersible hematite nanoparticles by zebrafish at different life stages.

The widespread use of nanoparticles (NPs) has drawn considerable attention because of their potential toxicity and the environmental consequences thereof. However, the effects of the exposure route an...

Uptake, depuration, bioaccumulation, and selective enrichment of dechlorane plus in common carp (Cyprinus carpio).

Dechlorane plus (DP) is a chlorinated flame retardant with high production volume (HPV) and is widely used in our daily necessities. In the present study, a laboratory-scale microcosm was built up to ...

Clinical Trials [2514 Associated Clinical Trials listed on BioPortfolio]

Xenotransplantation of Primary Cancer Samples in Zebrafish Embryos

The study consists in a co-clinical trial by using zebrafish embryos. Specifically, an observational prospective clinical trial on patients operated of epato-biliar-pancreatic cancers and ...

Influence of Protein Hydrolysis on Dietary Protein Digestibility and Metabolism in Healthy Subjects

Hydrolysis of dietary protein may impact their gastrointestinal kinetics and further metabolism. The primary goal of this work was to measure the metabolic fate of intact or hydrolyzed pro...

Biodistribution of 89Zirconium-labelled GSK2398852 Using PET Imaging

The principal aim of this study is to investigate the cardiac uptake of 89Zr-GSK2398852 in subjects with transthyretin cardiomyopathy amyloidosis (ATTR-CM), and its biodistribution to othe...

Assessment of the Biodistribution and Safety of [18F]MNI-968 in Healthy Subjects

The overall goal of this protocol is to evaluate the biodistribution of [18F]MNI-968 as a D1 receptor targeted radiopharmaceutical.

Assessment of the Biodistribution and Safety of [18F]MNI-958 in Healthy Subjects

The overall goal of this protocol is to evaluate the biodistribution of [18F]MNI-958 also known as APN-0000455 or PM-PBB3, as a tau targeted radiopharmaceutical.

Medical and Biotech [MESH] Definitions

Proteins obtained from the ZEBRAFISH. Many of the proteins in this species have been the subject of studies involving basic embryological development (EMBRYOLOGY).

Iron or iron compounds used in foods or as food. Dietary iron is important in oxygen transport and the synthesis of the iron-porphyrin proteins hemoglobin, myoglobin, cytochromes, and cytochrome oxidase. Insufficient amounts of dietary iron can lead to iron-deficiency anemia.

Phosphorus used in foods or obtained from food. This element is a major intracellular component which plays an important role in many biochemical pathways relating to normal physiological functions. High concentrations of dietary phosphorus can cause nephrocalcinosis which is associated with impaired kidney function. Low concentrations of dietary phosphorus cause an increase in calcitriol in the blood and osteoporosis.

Dietary recommendations that promote reduction in or prevention of high blood pressure. Recommendations include increasing intake of fruits and vegetables, and high-fiber, low-fat foods and reducing the intake of DIETARY SODIUM and high fat foods.

An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.

Quick Search

DeepDyve research library

Relevant Topics

Food is any substance consumed to provide nutritional support for the body. It is usually of plant or animal origin, and contains essential nutrients, such as carbohydrates, fats, proteins, vitamins, or minerals. The substance is ingested by an organism ...

Hepatology is the study of liver, gallbladder, biliary tree, and pancreas, and diseases associated with them. This includes viral hepatitis, alcohol damage, cirrhosis and cancer. As modern lifestyles change, with alcoholism and cancer becoming more promi...

Arthritis Fibromyalgia Gout Lupus Rheumatic Rheumatology is the medical specialty concerned with the diagnosis and management of disease involving joints, tendons, muscles, ligaments and associated structures (Oxford Medical Diction...

Searches Linking to this Article