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Antisense RNA world in bacteria.

07:00 EST 11th January 2020 | BioPortfolio

Summary of "Antisense RNA world in bacteria."

Bacteria exhibit an amazing diversity of mechanisms controlling gene expression to both maintain essential functions and modulate accessory functions in response to environmental cues. Over the years, it has become clear that bacterial regulation of gene expression is still far from fully understood. This review focuses on antisense RNAs (asRNAs), a class of RNA regulators defined by their location in cis and their perfect complementarity with their targets, as opposed to small RNAs (sRNAs) which act in trans with only short regions of complementarity. For a long time, only few functional asRNAs in bacteria were known and were almost exclusively found on mobile genetic elements (MGEs), thus, their importance among the other regulators was underestimated. However, the extensive application of global "omics" approaches has revealed the ubiquity of asRNAs in bacteria. This review aims, first, to describe the inherent ambiguity in the existence of asRNAs in bacteria, second, to highlight their diversity and their involvement in all aspects of bacterial life by presenting a list of 67 characterized asRNAs from both Gram-positive and Gram-negative bacteria.

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Name: Biochimica et biophysica acta. Gene regulatory mechanisms
ISSN: 1876-4320
Pages: 194489

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Medical and Biotech [MESH] Definitions

RNA molecules which hybridize to complementary sequences in either RNA or DNA altering the function of the latter. Endogenous antisense RNAs function as regulators of gene expression by a variety of mechanisms. Synthetic antisense RNAs are used to effect the functioning of specific genes for investigative or therapeutic purposes.

DNA that is complementary to the sense strand. (The sense strand has the same sequence as the mRNA transcript. The antisense strand is the template for mRNA synthesis.) Synthetic antisense DNAs are used to hybridize to complementary sequences in target RNAs or DNAs to effect the functioning of specific genes for investigative or therapeutic purposes.

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