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Inflammasome complex mediated interleukin 1β (IL-1β) and interleukin 18 (IL-18) production may be involved in immunopathogenesisof polycystic ovary syndrome (PCOS). Therefore, this study was conducted to investigate involvd inflammasome pathways in PCOS. Therefore, inflammasome genes expression and serum level of IL-1β were evaluated in 30 patients with confirmed PCOS and 30 women without PCOS. A remarkable increase in expression of the nucleotide binding and oligomerization domain (NOD)-like receptor (NLR) family pyrin domain-containing 3 (NALP3), absent in melanoma 2 (AIM2), IL-18 and associated speck-like protein containing a caspase recruitmentdomain(CARD); (ASC) genes in PCOS were observed (p <0.05). In contrast, expression level of NALP1, NALP12, NLR family apoptosis inhibitory proteins (NAIP), NLR family caspase recruitmentdomain(CARD) domain containing 4 (NLRC4) and IL-1β genes was not significant. Although the IL-1β protein level in serum of COS patients with BMI ≥ 25 was significantly higher than PCOS patient with BMI < 25, but there was no significant difference in non-PCOS individuals with BMI < 25 or ≥ 25. Furthermore, significant correlation between expression of AIM2 (r= 0.83, p=0.032) and NALP3 (r= 0.59, p=0.0001) was observed with IL-18, while a positive correlation (r= 0.84, p=0.0001) was revealed between NAIP and IL-1β. Based on the obtained results on inflammasome components along with increased expression of IL-1β especially in overweight patients, it can be concluded that IL-18 expression as well as IL-1β is probably due to activation of AIM2, NALP3 or NAIP inflammasome, which may play a critical role in immunopathology of PCOS.
This article was published in the following journal.
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The expression of a gene in an abnormal place, or at an abnormal time in an organism. Ectopic Gene Expression is often induced artificially by genetic techniques.
A form of gene interaction whereby the expression of one gene interferes with or masks the expression of a different gene or genes. Genes whose expression interferes with or masks the effects of other genes are said to be epistatic to the effected genes. Genes whose expression is affected (blocked or masked) are hypostatic to the interfering genes.
Techniques used to add in exogenous gene sequence such as mutated genes; REPORTER GENES, to study mechanisms of gene expression; or regulatory control sequences, to study effects of temporal changes to GENE EXPRESSION.
The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage.
The use of techniques that produce a functional MUTATION or an effect on GENE EXPRESSION of a specific gene of interest in order to identify the role or activity of the gene product of that gene.
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...
Women's Health - key topics include breast cancer, pregnancy, menopause, stroke Follow and track Women's Health News on BioPortfolio: Women's Health News RSS Women'...