Derivation of whole blood biomonitoring equivalents for lithium for the interpretation of biomonitoring data.

07:00 EST 11th January 2020 | BioPortfolio

Summary of "Derivation of whole blood biomonitoring equivalents for lithium for the interpretation of biomonitoring data."

Lithium salts have numerous industrial uses and are also used in the treatment of bipolar disorders. The main source of lithium exposure to the general population is drinking water and foods. Lithium is nephrotoxic at higher doses. Thus, oral exposure guidelines for lithium have been derived, including ICH's permitted daily exposure (PDE = 0.008 mg lithium/kg-bw/day) adopted by Health Canada and the United States Environmental Protection Agency's (U.S. EPA) provisional peer reviewed toxicity value (PPRTV = 0.002 mg lithium/kg-bw/day), both based on human data.


Journal Details

This article was published in the following journal.

Name: Regulatory toxicology and pharmacology : RTP
ISSN: 1096-0295
Pages: 104581


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