New reductant-free synthesis of gold nanoparticles-doped chitosan-based semi-IPN nanogel: A robust nanoreactor for exclusively sensitive 5-fluorouracil sensor.

07:00 EST 11th January 2020 | BioPortfolio

Summary of "New reductant-free synthesis of gold nanoparticles-doped chitosan-based semi-IPN nanogel: A robust nanoreactor for exclusively sensitive 5-fluorouracil sensor."

We report a novel class of chitosan (CS)-based hybrid semi-interpenetrating nanogel catalyst by the reductant-free green synthesis of gold nanoparticles (Au NPs) within the CS-poly(methacrylic acid) (Au@CS-PMAA) polymer network. The covalently cross-linked Au@CS-PMAA nanogel with CS chains semi-interpenetrating (semi-IPN) in the PMAA cross-linked network show superior colloidal stability and improved catalytic activity. The synthesized Au@CS-PMAA semi-IPN nanogel was applied as a superior modifier to create a new and sorely selective electrochemical sensing platform for the determination of antileukemic drug 5-fluorouracil (5-FU). The existence of -OH and -COOH groups in the CS and PMAA offers numerous binding sites for 5-FU. This assures the incorporation of Au NPs which affords a larger surface area and ameliorate electrical conductivity. Besides, the synergic effect amid both compounds improves the detection of 5-FU. Under optimal conditions, the constructed sensor offered a good performance in determination of 5-FU with a wide linear range from 0.1-497 μM and low detection limits of 0.03 μM, respectively. Further, this study proved that the fabricated sensor could be useful for analysis of 5-FU in actual human blood serum samples.


Journal Details

This article was published in the following journal.

Name: International journal of biological macromolecules
ISSN: 1879-0003


DeepDyve research library

PubMed Articles [25790 Associated PubMed Articles listed on BioPortfolio]

Plant-based gold nanoparticles; a comprehensive review of the decade-long research on synthesis, mechanistic aspects and diverse applications.

The worldwide focus on research in the field of green nanotechnology has resulted in the environmentally and biologically safe applications of a diversity of nanomaterials. Nanotechnology, in general,...

Facile fabrication of silver on magnetic nanocomposite (FeO@Chitosan -AgNP nanocomposite) for catalytic reduction of anthropogenic pollutant and agricultural pathogens.

In this work, a novel approach was developed to synthesis advance magnetic nano-catalyst; FeO@Chitosan -AgNP nanocomposite. It is made up of chitosan (fish industry-waste) doped onto the magnetic core...

Pectin-capped gold nanoparticles synthesis in-situ for producing durable, cytocompatible, and superabsorbent hydrogel composites with chitosan.

Studies report the production of gold nanoparticles (AuNPs) and polysaccharides-based composites. However, there are few reports about AuNPs synthesis in-situ followed by the formation of hydrogel com...

DNA Integration with Silver and Gold Nanoparticles. Enhancement of DNA Optical Anisotropy.

DNA integration with silver and gold nanoparticles was carried out by the chemical reduction of silver and gold ions after formation of their complexes with high molecular DNA in solution. It is shown...

Tuning of photo thermal and linear optical properties of eosin B dye with surfactant-free gold nanoparticles.

Exploring the interactions between gold nanoparticles and dye molecules is essentially significant, particularly for sensing, imaging and lasing applications. In this study, the gold nanoparticles wer...

Clinical Trials [7455 Associated Clinical Trials listed on BioPortfolio]

Chitosan,Chitosan Nanoparticles,and Chlorhexidine Gluconate, as Intra Canal Medicaments in Primary Teeth

Aim of the present study is to assess the in vivo susceptibility of root canal bacteria to Chitosan,Chitosan nanoparticles ,and Chlorhexidine gluconate when used as intra canal medicaments...

Effect of the Incoportation of Copper and Zinc Nanoparticles Into Dental Adhesives

The hypothesis is that Addition of copper or zinc nanoparticles to a dental adhesive confers antimicrobial and enzymatic degradation-resistant properties, retaining its adhesion mechanical...

Assessment of Pain and Antibacterial Activity of Chitosan Versus Sodium Hypochlorite as Irrigant in Infected Canal

A randomized clinical trial that aims to study the effect of chitosan nanoparticles (CS-np) versus sodium hypochlorite as a root canal irrigant on postoperative pain and antibacterial acti...

Efficacy and Safety of HEP-40 Chitosan for Mild to Moderately Elevated Cholesterol

Chitosan is a natural product that is produced commercially through the deacetylation of chitin, which is found in the exoskeleton of crustaceans. It has been suggested that chitosan has a...

Safety and Tolerability of Chitosan-N-acetylcysteine Eye Drops in Healthy Young Volunteers

The "dry eye syndrome" DES is a highly prevalent ocular disease, in particular in the elderly population. One mainstay of therapy for patients suffering from DES is the use of topically ad...

Medical and Biotech [MESH] Definitions

Nanoparticles produced from metals whose uses include biosensors, optics, and catalysts. In biomedical applications the particles frequently involve the noble metals, especially gold and silver.

Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.

The fusion of ceramics (porcelain) to an alloy of two or more metals for use in restorative and prosthodontic dentistry. Examples of metal alloys employed include cobalt-chromium, gold-palladium, gold-platinum-palladium, and nickel-based alloys.

Unstable isotopes of gold that decay or disintegrate emitting radiation. Au 185-196, 198-201, and 203 are radioactive gold isotopes.

Stable gold atoms that have the same atomic number as the element gold, but differ in atomic weight. Au-197 is a stable isotope.

Quick Search

DeepDyve research library

Relevant Topic

Drug Discovery
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...

Searches Linking to this Article