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The side effects and inefficiency of paclitaxel (PTX) in clinic have been became a major problem for cancer chemotherapy. The local drug delivery constructed by injectable hydrogel has been suggested as the alternative due to its superior properties such as tumor selectivity, minimally invasive administration and sustained drug release behavior. Polysaccharides have been commonly used as a gelling agent to constitute injectable hydrogel due to its wide resources, biocompatibility and bioactive functions. Here, we reported an injectable drug carrier with enhanced therapeutic effect based on Pinus koraiensis polysaccharide (PKP). Their interaction, morphology and mechanical properties were studied. Interestingly, gels exhibited excellent injectable property including rapid recovery time, excellent thixotropy ability and good rheological property after injection, and these special properties make them more proper to be constructed as an injectable drug carrier. In addition, the biocompatibility of gel was demonstrated in terms of hemolysis analysis. PTX-loaded gel showed excellent tumor inhibition effect against 4T1 and MCF-7 breast cancer cell lines in vitro, and exhibited the significant tumor growth suppression and reduced systemic toxicity in vivo. The successful construction of PTX-loaded gel demonstrates that PKP can be used as a promising carrier in local drug delivery.
This article was published in the following journal.
Name: International journal of biological macromolecules
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An injectable formulation of albumin-bound paclitaxel NANOPARTICLES.
Establishment of the level of a quantifiable effect indicative of a biologic process. The evaluation is frequently to detect the degree of toxic or therapeutic effect.
A type of viscous polysaccharide that is secreted from PLANTS. It has natural properties that are useful in the formulation of ADHESIVES.
An enzyme of long-chain fatty acid synthesis, that adds a two-carbon unit from malonyl-(acyl carrier protein) to another molecule of fatty acyl-(acyl carrier protein), giving a beta-ketoacyl-(acyl carrier protein) with the release of carbon dioxide. EC 18.104.22.168.
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<!--LGfEGNT2Lhm-->Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. <!--LGfEGNT2Lhm-->Drug delivery technologies are <!--LGfEGNT2Lhm-->patent pr...