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Cytokine gene variants and treatment outcome of cisplatin based concomitant chemoradiotherapy in cervical cancer.

07:00 EST 14th January 2020 | BioPortfolio

Summary of "Cytokine gene variants and treatment outcome of cisplatin based concomitant chemoradiotherapy in cervical cancer."

: Cervical cancer is the second most common cancer among women after breast cancer. Its standard treatment is cisplatin based concomitant chemoradiotherapy. Chronic inflammation in uterine cervix triggers both pro- and anti-inflammatory pathways. The unpredictability in toxicity and efficacy of treatment is a major challenge. We hypothesised a link between IL-1, IL-6 and TNF gene variants and treatment response.: We genotyped 246 cervical cancer cases and 246 controls by PCR, PCR-RFLP and ARMS-PCR. Treatment and response were evaluated by RECIST criteria. Chemotherapy and radiation doses were same for all patients, whilst 48 were followed-up for 36 month after treatment.: SNPs in and were linked with cervical cancer. Cases with certain allele combinations in (-597A/G) and showed odds ratios (95% CI) of up to 17.54 (2.7-24.08) for the presence of cervical cancer. Variant (-511T/C) was linked to vital status but none were linked to overall survival. Certain cytokine gene variants may help detect susceptibiliy to cervical cancer, and predict response to chemoradiotherapy.

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This article was published in the following journal.

Name: British journal of biomedical science
ISSN: 0967-4845
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