Cytokine gene variants and treatment outcome of cisplatin based concomitant chemoradiotherapy in cervical cancer.

07:00 EST 14th January 2020 | BioPortfolio

Summary of "Cytokine gene variants and treatment outcome of cisplatin based concomitant chemoradiotherapy in cervical cancer."

: Cervical cancer is the second most common cancer among women after breast cancer. Its standard treatment is cisplatin based concomitant chemoradiotherapy. Chronic inflammation in uterine cervix triggers both pro- and anti-inflammatory pathways. The unpredictability in toxicity and efficacy of treatment is a major challenge. We hypothesised a link between IL-1, IL-6 and TNF gene variants and treatment response.: We genotyped 246 cervical cancer cases and 246 controls by PCR, PCR-RFLP and ARMS-PCR. Treatment and response were evaluated by RECIST criteria. Chemotherapy and radiation doses were same for all patients, whilst 48 were followed-up for 36 month after treatment.: SNPs in and were linked with cervical cancer. Cases with certain allele combinations in (-597A/G) and showed odds ratios (95% CI) of up to 17.54 (2.7-24.08) for the presence of cervical cancer. Variant (-511T/C) was linked to vital status but none were linked to overall survival. Certain cytokine gene variants may help detect susceptibiliy to cervical cancer, and predict response to chemoradiotherapy.


Journal Details

This article was published in the following journal.

Name: British journal of biomedical science
ISSN: 0967-4845


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