Topics

The dynamics of shapes of vesicle membranes with time dependent spontaneous curvature.

07:00 EST 14th January 2020 | BioPortfolio

Summary of "The dynamics of shapes of vesicle membranes with time dependent spontaneous curvature."

We study the time evolution of the shape of a vesicle membrane under time-dependent spontaneous curvature by means of phase-field model. We introduce the variation in time of the spontaneous curvature via a second field which represents the concentration of a substance that anchors with the lipid bilayer thus changing the local curvature and producing constriction. This constriction is mediated by the action on the membrane of an structure resembling the role of a Z ring. Our phase-field model is able to reproduce a number of different shapes that have been experimentally observed. Different shapes are associated with different constraints imposed upon the model regarding conservation of membrane area. In particular, we show that if area is conserved our model reproduces the so-called L-form shape. By contrast, if the area of the membrane is allowed to grow, our model reproduces the formation of a septum in the vicinity of the constriction. Furthermore, we propose a new term in the free energy which allows the membrane to evolve towards eventual pinching.

Affiliation

Journal Details

This article was published in the following journal.

Name: PloS one
ISSN: 1932-6203
Pages: e0227562

Links

DeepDyve research library

PubMed Articles [19520 Associated PubMed Articles listed on BioPortfolio]

Structure and dynamics of lipid membranes interacting with antivirulence end-phosphorylated polyethylene glycol block copolymers.

The structure and dynamics of lipid membranes in the presence of extracellular macromolecules are critical for cell membrane functions and many pharmaceutical applications. The pathogen virulence-supp...

Barcoding biological reactions with DNA-functionalized vesicles.

Targeted vesicle fusion is a promising approach to selectively control interactions between vesicle compartments and would enable the initiation of biological reactions in complex aqueous environments...

Detachment of a fluid membrane from a substrate and vesiculation.

The detachment dynamics of a fluid membrane with isotropic spontaneous curvature from a flat substrate are studied by using meshless membrane simulations. The membrane is detached from an open edge le...

Phosphatidylserine is critical for vesicle fission during clathrin-mediated endocytosis.

Phosphatidylserine (PS), a negatively charged phospholipid present predominantly at the inner leaflet of the plasma membrane, has been widely implicated in many cellular processes including membrane t...

SuAVE: A Tool for Analyzing Curvature-Dependent Properties in Chemical Interfaces.

Curvature is an intrinsic feature of biological membranes underlying vital cellular processes such as endocytosis, membrane fusion-fission, trafficking and remodeling. The continuous expansion of the ...

Clinical Trials [4696 Associated Clinical Trials listed on BioPortfolio]

Azithromycin for Preterm Pre-labor Rupture of Membranes

The preterm prelabour rupture of membranes is defined as the spontaneous rupture of the fetal membranes before 37 completed weeks. Preterm prelabour rupture of membranes complicates up to ...

Glucose-dependent Asprosin Dynamics

The study entitled " Asprosin Dynamics relating to serum Glucose levels under controlled alterations" investigates the dynamics of Asprosin in relation to glucose levels under controlled c...

Best Cutoff Value of Lactate Concentration in Vaginal Fluid to Predict Time of Spontaneous Onset of Labor in PPROM

The present study is aimed to assess whether lactate determination in vaginal fluid is associated with and can predict onset of labor for women with suspected preterm prelabor rupture of m...

Time,Self and Spontaneous Mental Activities in Patients With Psychotic Disorders

The main purpose of the study is to examine to which extent abnormalities in the dynamics of neural activities observed in patients with psychosis is related to difficulties at ordering si...

Does Nipple Stimulation Shorten Time to Vaginal Birth in Women With Term PROM?

Premature Rupture of Membranes (PROM) is defined as the rupture of membranes before the onset of regular uterine contractions. PROM occurs in approximately 10% of all pregnancies (ranging...

Medical and Biotech [MESH] Definitions

Spontaneous tearing of the membranes surrounding the FETUS any time before the onset of OBSTETRIC LABOR. Preterm PROM is membrane rupture before 37 weeks of GESTATION.

A spontaneous diminution or abatement of a disease over time, without formal treatment.

The study of systems which respond disproportionately (nonlinearly) to initial conditions or perturbing stimuli. Nonlinear systems may exhibit "chaos" which is classically characterized as sensitive dependence on initial conditions. Chaotic systems, while distinguished from more ordered periodic systems, are not random. When their behavior over time is appropriately displayed (in "phase space"), constraints are evident which are described by "strange attractors". Phase space representations of chaotic systems, or strange attractors, usually reveal fractal (FRACTALS) self-similarity across time scales. Natural, including biological, systems often display nonlinear dynamics and chaos.

A computer simulation developed to study the motion of molecules over a period of time.

Absorption, metabolism and elimination of drugs in relation to time of day at which they are administered, and the mechanisms responsible for time-dependent variations.

Quick Search


DeepDyve research library

Searches Linking to this Article