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Exercise training and antioxidant supplementation may improve unintentional weight loss and programmed cell death associated with cancer cachexia. The aim of this study was to examine the alterations of body weight and apoptotic indices in skeletal muscle of 4T1 breast cancer-bearing mice with cachexia following 4 weeks of high-intensity interval training (HIIT) and saffron aqueous extract (SAE) supplementation. Female BALB/c mice following induction of breast cancer were divided into (1) controls, (2) HIIT, (3) SAE, (4) HIIT+ SAE, and (5) sham groups. Mice were euthanized and gastrocnemius muscle was collected after intervention. The control group elicited a significant weight reduction during 3rd and 4th weeks of tumor injection, while other treatments like HIIT and SAE, not HIIT+SAE showed to counteract this adverse event. Furthermore, HIIT and SAE treatments (not HIIT+ SAE) demonstrated reduced caspase-3 and Bax levels than the control group. The level of Bcl-2 was elevated following both HIIT and SAE treatments than the control group. Finally, the ratio of Bcl-2 to Bax was significantly higher in both HIIT and SAE groups, but lower in HIIT+SAE group than sham group. It is likely that either HIIT or SAE intervention alone (not HIIT+ SAE) represents a readily applicable approach in the regulation of muscle wasting and apoptosis in cancer cachexia. Novelty • HIIT is associated with a reduced risk of cancer- related muscle wasting. • SAE improvement the muscle wasting through reduce apoptosis indices. • Combination of HIIT and SAE does not improve cancer-related loss of muscle mass and mediate apoptotic activation.
This article was published in the following journal.
Name: Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
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A genus of poisonous, liliaceous plants. The roots (corms) of Colchicum autumnale, the fall crocus or meadow saffron, yield COLCHICINE, which is used as a biochemical tool and to treat gout. Other members of this genus yield saffron dye, flavoring agents, and aromatics.
A plant genus of the family ASTERACEAE. The common name of thoroughwort is also used for other plants including EUPATORIUM; CHROMOLAENA, Hebeclinium and Koanophyllon. Eupolin is the aqueous extract of the leaves.
A dehydrated extract of thyroid glands. After the removal of fat and connective tissue, the extract is dried or lyophilized to yield a yellowish to buff-colored amorphous powder containing 0.17-0.23% of iodine.
Arthritis Fibromyalgia Gout Lupus Rheumatic Rheumatology is the medical specialty concerned with the diagnosis and management of disease involving joints, tendons, muscles, ligaments and associated structures (Oxford Medical Diction...