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Salvia hispanica L., commonly known as chia seed, has beneficial effects upon some signs of metabolic syndrome (MS), such as dyslipidemia and insulin resistance. However, its action on cardiac oxidative stress associated with MS remains unknown. The goal of this study was to analyze the possible beneficial effects of chia seed (variety Salba) upon the oxidative stress of left ventricle heart muscle (LV) of a well established dyslipidemic insulin-resistant rat model induced by feeding them a sucrose-rich diet (SRD). Male Wistar rats received an SRD for three months. After that, for three additional months, half of the animals continued with the SRD, while the other half received the SRD containing chia as the source of dietary fat instead corn oil (SRD+chia). In the LV of SRD-fed rats, chia seed improved/reverted the depleted activity of antioxidant enzymes glutathione peroxidase, superoxide dismutase (SOD), and catalase, and ameliorated MnSOD mRNA levels increasing the expression of the nuclear factor Nrf2. Improved the glutathione redox estate, reactive oxygen species, and TBARS contents normalizing the p47NOX subunit mRNA level. Furthermore, chia normalized hypertension and plasma levels of pro-inflammatory cytokines and oxidative stress biomarkers. The findings show that chia seed intake impacts positively upon oxidative unbalance of LV of dyslipidemic insulin-resistant rats. Bullet points: ●Healthy effects of chia seed involve an improvement of cardiac antioxidant defenses through Nrf2 induction. ●Chia seed intake reduces cardiac oxidative stress markers of dyslipemic insulin-resistant rats. ●Dietary chia seed restores cardiac unbalanced redox state of dyslipemic insulin-resistant rats.
This article was published in the following journal.
Name: Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
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A plant species of the Salvia genus known as a spice and medicinal plant.
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