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Single fluoride substitution in trifluoromethylarenes is an ongoing synthetic challenge that often leads to 'over-reaction', where multiple fluorides are replaced. Development of this reaction would allow simple access to a vast range of difluorome-thyl derivatives of current interest to pharmaceutical, agrochemistry and materials sciences. Using a Frustrated Lewis Pair approach, we have developed a generic protocol that allows a single substitution of one fluoride in trifluoromethyl groups with neutral phosphine and pyridine bases. The resulting phosphonium and pyridinium salts can be further functionalized via nucleophilic substitution, photoredox coupling and electrophilic transfer reactions allowing the generation of a vast array of difluoromethyl products.
This article was published in the following journal.
Name: Journal of the American Chemical Society
Dihydrogen was readily activated by combination of homoleptic rare-earth metal aryloxides, RE(OAr)3 (RE = La, Sm, and Y) with N-heterocyclic carbenes (NHCs) under mild conditions. RE(OAr)3 were found ...
Metal-free catalysis by sterically encumbered Lewis Acid-Base pairs, popularly known as frustrated Lewis pairs (), is gaining importance by the day due to its promise of providing a greener alternativ...
The photocatalytic activity of nanostructured In2O3-x(OH)y for the Reverse Water Gas Shift (RWGS) Reaction CO2 + H2 → CO + H2O can be greatly enhanced by substitution of Bi(III) for In(III) in the l...
The concept of frustrated Lewis pairs (FLPs) has been widely applied into various research areas, and the metal-free hydrogenation undoubtedly belongs to the most significant and successful ones. In t...
The aim was to measure and compare fluoride concentrations in oral mucosa and saliva following a single brushing with either 1,450 or 5,000 ppm fluoride toothpaste. Fourteen healthy participants provi...
This will be a randomized, controlled, single center, single- blind, 3 period, 3 treatment, cross-over, in situ design which consists of placing pre-eroded bovine enamel specimens intra or...
This study is to evaluate the amount of fluoride in plaque fluid after brushing iwth fluoride dentifrices
Surgery is still the main treatment for esophageal cancer, however, the complication and mortality rate of open esophagectomy is high. As a result, the thoracoscopic- laparoscopic minimall...
The study was carried out in 88 children with severe early childhood caries (dmfs≥age +1) who were referred to the investigators' clinic. Patients who completed dental treatment under ge...
The aim of this study is to assess the impact of formulation differences on fluoride retention clearance with US levels of fluoride (1150 ppm of fluoride) by evaluating and comparing betwe...
Any chemical species which accepts an electron-pair from a LEWIS BASE in a chemical bonding reaction.
Any chemical species which acts as an electron-pair donor in a chemical bonding reaction with a LEWIS ACID.
A mutation caused by the substitution of one nucleotide for another. This results in the DNA molecule having a change in a single base pair.
Calcium fluoride. Occurring in nature as the mineral fluorite or fluorspar. It is the primary source of fluorine and its compounds. Pure calcium fluoride is used as a catalyst in dehydration and dehydrogenation and is used to fluoridate drinking water. (From Merck Index, 11th ed)
A source of inorganic fluoride which is used topically to prevent dental caries.
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...
A diagnostic test is any kind of medical test performed to aid in the diagnosis or detection of disease. For example: to diagnose diseases to measure the progress or recovery from disease to confirm that a person is free from disease Clin...