Topics

Frustrated Lewis pair meditated selective single fluoride substitution in trifluoromethyl groups.

07:00 EST 14th January 2020 | BioPortfolio

Summary of "Frustrated Lewis pair meditated selective single fluoride substitution in trifluoromethyl groups."

Single fluoride substitution in trifluoromethylarenes is an ongoing synthetic challenge that often leads to 'over-reaction', where multiple fluorides are replaced. Development of this reaction would allow simple access to a vast range of difluorome-thyl derivatives of current interest to pharmaceutical, agrochemistry and materials sciences. Using a Frustrated Lewis Pair approach, we have developed a generic protocol that allows a single substitution of one fluoride in trifluoromethyl groups with neutral phosphine and pyridine bases. The resulting phosphonium and pyridinium salts can be further functionalized via nucleophilic substitution, photoredox coupling and electrophilic transfer reactions allowing the generation of a vast array of difluoromethyl products.

Affiliation

Journal Details

This article was published in the following journal.

Name: Journal of the American Chemical Society
ISSN: 1520-5126
Pages:

Links

DeepDyve research library

PubMed Articles [11433 Associated PubMed Articles listed on BioPortfolio]

Dihydrogen activation by intermolecular rare-earth aryloxide/N-heterocyclic carbene Lewis pairs.

Dihydrogen was readily activated by combination of homoleptic rare-earth metal aryloxides, RE(OAr)3 (RE = La, Sm, and Y) with N-heterocyclic carbenes (NHCs) under mild conditions. RE(OAr)3 were found ...

Frustrated Lewis Acid-Base-Pair-Catalyzed Amine-Borane Dehydrogenation.

Metal-free catalysis by sterically encumbered Lewis Acid-Base pairs, popularly known as frustrated Lewis pairs (), is gaining importance by the day due to its promise of providing a greener alternativ...

Synergistic coupling of Photo and Thermal conditions for Enhancing CO2 Reduction Rates in the Reverse Water Gas Shift Reaction.

The photocatalytic activity of nanostructured In2O3-x(OH)y for the Reverse Water Gas Shift (RWGS) Reaction CO2 + H2 → CO + H2O can be greatly enhanced by substitution of Bi(III) for In(III) in the l...

Asymmetric Hydrogenations of Ketones and Enones with Chiral Lewis Base-Led Frustrated Lewis Pairs.

The concept of frustrated Lewis pairs (FLPs) has been widely applied into various research areas, and the metal-free hydrogenation undoubtedly belongs to the most significant and successful ones. In t...

Fluoride in Saliva and Oral Mucosa after Brushing with 1,450 or 5,000 ppm Fluoride Toothpaste.

The aim was to measure and compare fluoride concentrations in oral mucosa and saliva following a single brushing with either 1,450 or 5,000 ppm fluoride toothpaste. Fourteen healthy participants provi...

Clinical Trials [4599 Associated Clinical Trials listed on BioPortfolio]

In Situ Erosion Study to Investigate the Effectiveness of an Experimental Toothpaste

This will be a randomized, controlled, single center, single- blind, 3 period, 3 treatment, cross-over, in situ design which consists of placing pre-eroded bovine enamel specimens intra or...

Evaluation of Plaque Fluid Fluoride Retention From Fluoride Toothpastes

This study is to evaluate the amount of fluoride in plaque fluid after brushing iwth fluoride dentifrices

A Comparison Between Ivor-Lewis and McKeown Minimally Invasive Esophagectomy

Surgery is still the main treatment for esophageal cancer, however, the complication and mortality rate of open esophagectomy is high. As a result, the thoracoscopic- laparoscopic minimall...

Effectiveness Fluoride Varnishes in Children With Early Childhood Caries

The study was carried out in 88 children with severe early childhood caries (dmfs≥age +1) who were referred to the investigators' clinic. Patients who completed dental treatment under ge...

Intra Oral Kinetics of Fluoride Containing Dentifrices in a Modified Saliva Clearance Study

The aim of this study is to assess the impact of formulation differences on fluoride retention clearance with US levels of fluoride (1150 ppm of fluoride) by evaluating and comparing betwe...

Medical and Biotech [MESH] Definitions

Any chemical species which accepts an electron-pair from a LEWIS BASE in a chemical bonding reaction.

Any chemical species which acts as an electron-pair donor in a chemical bonding reaction with a LEWIS ACID.

A mutation caused by the substitution of one nucleotide for another. This results in the DNA molecule having a change in a single base pair.

Calcium fluoride. Occurring in nature as the mineral fluorite or fluorspar. It is the primary source of fluorine and its compounds. Pure calcium fluoride is used as a catalyst in dehydration and dehydrogenation and is used to fluoridate drinking water. (From Merck Index, 11th ed)

A source of inorganic fluoride which is used topically to prevent dental caries.

Quick Search


DeepDyve research library

Relevant Topics

Drug Discovery
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...

Diagnostics
A diagnostic test is any kind of medical test performed to aid in the diagnosis or detection of disease. For example: to diagnose diseases to measure the progress or recovery from disease to confirm that a person is free from disease Clin...


Searches Linking to this Article