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Activatable fluorescence probes for "turn-on" and ratiometric biosensing and bioimaging: from NIR-I to NIR-II.

07:00 EST 14th January 2020 | BioPortfolio

Summary of "Activatable fluorescence probes for "turn-on" and ratiometric biosensing and bioimaging: from NIR-I to NIR-II."

The most advantage of activatable fluorescence probes (AFPs) is their inherent responsivity to environmental factors/analytes, and the spectroscopic properties of AFPs could be manipulated through control of chemical/physical interactions with biological targets. As alternatives to "always-on" fluorescence probes, AFPs in the near-infrared I (NIR-I) window have expanded dramatically in the past decade and have emerged as an indispensable tool in the development and application of biosensing and bioimaging. Benefiting from the decreasing scattering coefficient of different biological tissues and negligible autofluorescence within longer wavelength, recent progress of near-infrared II (NIR-II) fluorescent materials has been creating vast new opportunities in developing AFPs. Here we review, the current role of AFPs in biosensing and bioimaging, with emphasize on NIR-II AFPs developed for biomedical applications. The challenges and prospects of AFPs are also discussed by considering the clinical translation from bench to bedside.

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Name: Bioconjugate chemistry
ISSN: 1520-4812
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