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Multi-Stimulus Responsive Biointerfaces with Switchable Bioadhesion and Surface Functions.

07:00 EST 14th January 2020 | BioPortfolio

Summary of "Multi-Stimulus Responsive Biointerfaces with Switchable Bioadhesion and Surface Functions."

Stimuli-responsive biointerfaces can serve as dynamic tools for modulation of biointerfacial interactions. Considering the complexity of biological environments, surfaces with multi-stimulus responsive switchable bioactivity are of great interest. In the work reported herein, a multi-stimulus responsive biointerface with on-off switchable bioadhesion (protein adsorption, bacterial adhesion and cell adhesion) and surface functions in response to change in temperature, pH or sugar content is developed. This surface is based on silicon modified with a copolymer containing a thermo-responsive component (poly(N-isopropylacrylamide)) and a component, phenylboronic acid, that can form pH-responsive and sugar-responsive dynamic boronate ester bonds with diol-containing molecules. It is shown that biointeractions including protein adsorption and release, bacteria and cell attachment and detachment on this surface can be regulated by changing temperature, pH, and sugar content of the medium, either individually or all three simultaneously. Furthermore, this surface can switch between two different functions, namely between killing and releasing bacteria, by introduction of a diol-containing biocidal compound. Compared to switchable surfaces that are responsive to only one stimulus, our multi-stimulus responsive surface is better adapted to respond to the multifunctional complexities of the biological environment, and thus has potential for use in numerous biomedical and biotechnology applications.

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This article was published in the following journal.

Name: ACS applied materials & interfaces
ISSN: 1944-8252
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