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Stimuli-responsive biointerfaces can serve as dynamic tools for modulation of biointerfacial interactions. Considering the complexity of biological environments, surfaces with multi-stimulus responsive switchable bioactivity are of great interest. In the work reported herein, a multi-stimulus responsive biointerface with on-off switchable bioadhesion (protein adsorption, bacterial adhesion and cell adhesion) and surface functions in response to change in temperature, pH or sugar content is developed. This surface is based on silicon modified with a copolymer containing a thermo-responsive component (poly(N-isopropylacrylamide)) and a component, phenylboronic acid, that can form pH-responsive and sugar-responsive dynamic boronate ester bonds with diol-containing molecules. It is shown that biointeractions including protein adsorption and release, bacteria and cell attachment and detachment on this surface can be regulated by changing temperature, pH, and sugar content of the medium, either individually or all three simultaneously. Furthermore, this surface can switch between two different functions, namely between killing and releasing bacteria, by introduction of a diol-containing biocidal compound. Compared to switchable surfaces that are responsive to only one stimulus, our multi-stimulus responsive surface is better adapted to respond to the multifunctional complexities of the biological environment, and thus has potential for use in numerous biomedical and biotechnology applications.
This article was published in the following journal.
Name: ACS applied materials & interfaces
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Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079)
The tendency to react to stimuli that are different from, but somewhat similar to, the stimulus used as a conditioned stimulus.
The directional growth of an organism in response to an external stimulus such as light, touch, or gravity. Growth towards the stimulus is a positive tropism; growth away from the stimulus is a negative tropism. (From Concise Dictionary of Biology, 1990)
Learning that takes place when a conditioned stimulus is paired with an unconditioned stimulus.
The principle that after an organism learns to respond in a particular manner to a stimulus, that stimulus is effective in eliciting similar responses.
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