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Fabrication of collagen films with enhanced mechanical and enzymatic stability through thermal treatment in fluorous media.

07:00 EST 14th January 2020 | BioPortfolio

Summary of "Fabrication of collagen films with enhanced mechanical and enzymatic stability through thermal treatment in fluorous media."

Collagen I (Col-I) is widely used in the fabrication of biomaterials due to its biocompatibility, however Col-I based biomaterials are susceptible to mechanical failure during handling, which limits their applicability to biomaterials. Chemical or physical treatment can improve the mechanical properties of collagen however, these processes can create issues of cytotoxicity or denaturation. We report here an alternative strategy to improve the stability and mechanical properties of Col-I while preserving its native structure, through thermal treatment in fluorous media. Thermal treatment of Col-I in fluorous solvent generates compact, stable films with significantly increased mechanical strength. Furthermore, the use of fluorous media significantly reduces the extent of swelling, rate of proteolytic degradation, and preserves the high cell biocompatibility.

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This article was published in the following journal.

Name: ACS applied materials & interfaces
ISSN: 1944-8252
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