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An additional analysis of the efficacy and safety of therapy in the Russian population of patients with multiple sclerosis participated in phase III international multicenter clinical trials: results of alemtuzumab study.

07:00 EST 1st January 2019 | BioPortfolio

Summary of "An additional analysis of the efficacy and safety of therapy in the Russian population of patients with multiple sclerosis participated in phase III international multicenter clinical trials: results of alemtuzumab study."

The article is discussing the data of additional analyses of subpopulation of MS patients from Russia, participating in phase III clinical trials of DMTs (article by E.P. Evdoshenko et al in this issue). This review the data of alemtuzumab trials CARE-MS I and CARE-MS II with special attention to Russian patients. Such statistics allows to find new peculiarities of the drug effectiveness, selection of groups of patients, showing better results in MS patients with high disease activity, but low residual disability. Data of longitudinal observations are of special interest. Presented data on the 8-years observation of MS after alemtuzumab therapy show low annual relapse rate (mean 0,14-0,18) and stable disability levels, even with confimed disability improvement of EDSS in 41-47% of patients.

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Name: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
ISSN: 1997-7298
Pages: 147-152

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