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Evaluation of apparent diffusion coefficient as a predictor of grade reclassification in men on active surveillance for prostate cancer.

07:00 EST 15th January 2020 | BioPortfolio

Summary of "Evaluation of apparent diffusion coefficient as a predictor of grade reclassification in men on active surveillance for prostate cancer."

To evaluate the association between apparent diffusion coefficient (ADC) on initial multiparametric MRI (mpMRI) and biopsy grade reclassification (GR) to Grade Group (GG) ≥ 2 prostate cancer (PCa) in men on active surveillance (AS) with GG 1 PCa.

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This article was published in the following journal.

Name: Urology
ISSN: 1527-9995
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Medical and Biotech [MESH] Definitions

A diagnostic technique that incorporates the measurement of molecular diffusion (such as water or metabolites) for tissue assessment by MRI. The degree of molecular movement can be measured by changes of apparent diffusion coefficient (ADC) with time, as reflected by tissue microstructure. Diffusion MRI has been used to study BRAIN ISCHEMIA and tumor response to treatment.

The use of diffusion ANISOTROPY data from diffusion magnetic resonance imaging results to construct images based on the direction of the faster diffusing molecules.

A method used to study the lateral movement of MEMBRANE PROTEINS and LIPIDS. A small area of a cell membrane is bleached by laser light and the amount of time necessary for unbleached fluorescent marker-tagged proteins to diffuse back into the bleached site is a measurement of the cell membrane's fluidity. The diffusion coefficient of a protein or lipid in the membrane can be calculated from the data. (From Segen, Current Med Talk, 1995).

The tendency of a gas or solute to pass from a point of higher pressure or concentration to a point of lower pressure or concentration and to distribute itself throughout the available space. Diffusion, especially FACILITATED DIFFUSION, is a major mechanism of BIOLOGICAL TRANSPORT.

The processes of diffusion across the BLOOD-AIR BARRIER, and the chemical reactions coupled with diffusion that effect the rate of PULMONARY GAS EXCHANGE, generally at the alveolar level.

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