Effect of Sunscreen Application on Plasma Concentration of Sunscreen Active Ingredients: A Randomized Clinical Trial.

07:00 EST 21st January 2020 | BioPortfolio

Summary of "Effect of Sunscreen Application on Plasma Concentration of Sunscreen Active Ingredients: A Randomized Clinical Trial."

A prior pilot study demonstrated the systemic absorption of 4 sunscreen active ingredients; additional studies are needed to determine the systemic absorption of additional active ingredients and how quickly systemic exposure exceeds 0.5 ng/mL as recommended by the US Food and Drug Administration (FDA).


Journal Details

This article was published in the following journal.

Name: JAMA
ISSN: 1538-3598
Pages: 256-267


DeepDyve research library

PubMed Articles [27578 Associated PubMed Articles listed on BioPortfolio]

Effect of Sunscreen Application Under Maximal Use Conditions on Plasma Concentration of Sunscreen Active Ingredients: A Critical Appraisal.

Matta KM et al conducted a Phase 1 randomised controlled trial (RCT) to investigate whether four organic UVR filters in four commercially available sunscreens (2 sprays, 1 lotion, 1 cream) were system...

The Influence of Short-Wave and Long-Wave Radiation Spectrum on the Photostability of Sunscreens.

Sunscreen products aim to help protect the skin against UV radiation and consequently reduce the risk of early skin ageing and skin cancer. However, it is well known that some sunscreen ingredients ar...

Materials Science Challenges in Skin UV Protection: A Review.

UV radiation is one of the critical environmental stress factors for human skin, which can trigger various problems such as pruritus, burning, erythema, premature skin aging, and skin cancer. Hence, U...

Spray sunscreen: characterizing application area density and implications for sun protection.

Improving Photoprotection and Implications for 25(OH)D Formation.

This review examined the implications of using sunscreen photoprotection on 25(OH)D formation and determined the best photoprotective method to reduce the risk of skin cancer caused by ultraviolet rad...

Clinical Trials [12588 Associated Clinical Trials listed on BioPortfolio]

Assessment of the Human Systemic Absorption of Sunscreen Ingredients

This study is designed to assess the systemic exposure and pharmacokinetics of sunscreen active ingredients (avobenzone, oxybenzone, ecamsule and octocrylene) when sunscreen product is app...

Sunscreen: Persistence of Sun Protection Factor and the Influence on Vitamin D

The investigators want to investigate whether sunscreen is removed by clothing and to what extend when the amount of sunscreen applied varies.Does clothing reduce the SPF when clothes are ...

Determination of Sun Protection in Sunscreen Formulas (Study SR09-15)(P08236)(COMPLETED)

Study to determine the sunscreen protection factor (SPF) and ultraviolet A protection factor (PFA) of 2 sunscreen products containing the combination of zinc oxide and avobenzone with and ...

Cost and Quality in Consumer Sunscreen Preferences

This study seeks to determine what price consumers are willing to pay for a sunscreen product containing their ideal combination of attributes or qualities. This study will assess consumer...

How Useful is the Advice: "Fill up a Handful of Sunscreen and Spread it All Over Your Body"

The advice: "Fill up a handful of sunscreen and spread it all over your body" is used in several sun safety campaigns. The hope is that users in swimwear following the advice will apply a ...

Medical and Biotech [MESH] Definitions

7-Hydroxycoumarins. Substances present in many plants, especially umbelliferae. Umbelliferones are used in sunscreen preparations and may be mutagenic. Their derivatives are used in liver therapy, as reagents, plant growth factors, sunscreens, insecticides, parasiticides, choleretics, spasmolytics, etc.

A genus of brown-rot fungi in the family Coriolaceae. The biologically active ingredients of its species have potential pharmaceutical value.

The concentration of osmotically active particles in solution expressed in terms of osmoles of solute per liter of solution. Osmolality is expressed in terms of osmoles of solute per kilogram of solvent.

In humans it may be irritating to mucous membranes. Methemoglobinemia has been produced experimentally. In veterinary use, it is one of active ingredients in topical agents for prevention and treatment of screwworm infestation. An indicator in tests for nitrate poisoning.

Calcium-transporting ATPases found on the PLASMA MEMBRANE that catalyze the active transport of CALCIUM from the CYTOPLASM into the extracellular space. They play a role in maintaining a CALCIUM gradient across plasma membrane.

Quick Search

DeepDyve research library

Relevant Topics

Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells.  In vertebrates, it is composed of blo...

Clincial Trials
In a clinical trial or interventional study, participants receive specific interventions according to the research plan or protocol created by the investigators. These interventions may be medical products, such as drugs or devices; procedures; or change...

Searches Linking to this Article