DRIMC: an improved drug repositioning approach using Bayesian inductive matrix completion.

07:00 EST 30th January 2020 | BioPortfolio

Summary of "DRIMC: an improved drug repositioning approach using Bayesian inductive matrix completion."

One of the most important problems in drug discovery research is to precisely predict a new indication for an existing drug, i.e. drug repositioning. Recent recommendation system-based methods have tackled this problem using matrix completion models. The models identify latent factors contributing to known drug-disease associations, and then infer novel drug-disease associations by the correlations between latent factors. However, these models have not fully considered the various drug data sources and the sparsity of the drug-disease association matrix. In addition, using the global structure of the drug-disease association data may introduce noise, and consequently limit the prediction power.


Journal Details

This article was published in the following journal.

Name: Bioinformatics (Oxford, England)
ISSN: 1367-4811


DeepDyve research library

PubMed Articles [18634 Associated PubMed Articles listed on BioPortfolio]

Structure-based Drug repositioning: Potential and Limits.

Drug repositioning, the assignment of new therapeutic purposes to known drugs, is an established strategy with many repurposed drugs on the market and many more at experimental stage. We review three ...

A Review of Recent Developments and Progress in Computational Drug Repositioning.

Computational drug repositioning is an efficient approach towards discovering new indications for existing drugs. In recent years, with the accumulation of online health-related information and the ex...

Systems biology based drug repositioning for development of cancer therapy.

Drug repositioning is a powerful method that can assists the conventional drug discovery process by using existing drugs for treatment of a disease rather than its original indication. The first examp...

Drug repositioning via matrix completion with multi-view side information.

In the process of drug discovery and disease treatment, drug repositioning is broadly studied to identify biological targets for existing drugs. Many methods have been proposed for drug-target interac...

Therapeutic Drug Monitoring Coupled with Bayesian Forecasting could Prevent Vancomycin-associated Nephrotoxicity in Renal Insufficiency Patients: A Prospective Study and Pharmacoeconomic Analysis.

Vancomycin is a critical antibiotic used in important infections, and therapeutic drug monitoring is recommended. Bayesian forecasting is demonstrated to provide an approach that can improve trough co...

Clinical Trials [7228 Associated Clinical Trials listed on BioPortfolio]

Efficiency of the Super Inductive System in Spasticity Treatment

The aim of the study is to see whether a physical therapy program can relieve pain, decrease spasticity and increase muscle contraction force by using the super inductive system (high freq...

Preventing Pressure Ulcers With Repositioning Frequency and Precipitating Factors

The purpose of this study is to determine whether repositioning frequency can be extended for nursing home (NH) residents who are low, moderate, and high risk for pressure ulcer (PrU) deve...

Electronic Repositioning With Acuity and Easytrak Leads

Evaluate appropriate performance of Electronic Repositioning™ (ER) in the clinical routine, cumulative incidence of phrenic nerve stimulation (PNS) & success rates of ER to remove it, v...

Comparison of Two Dosage Adjustment Strategies of Vancomycin in Children

Vancomycin is the standard first-line treatment for MRSA infections and a first-line empiric therapy. The relationship between exposure to vancomycin and efficacy is admitted but because o...

Evaluating Lip Repositioning for the Treatment of Excess Gingival Display With and Without Pretreatment With Botox

Since the introduction of the lip repositioning procedure by a number of modifications to the technique have been introduced. All these modifications were made to prevent the main complica...

Medical and Biotech [MESH] Definitions

The deliberate and methodical practice of finding new applications for existing drugs.

An integrated nano-scale approach to MEDICINE which involves concurrent diagnosis, drug delivery, therapy, and monitoring of therapeutic response.

Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.

Any situation where an animal or human is trained to respond differentially to two stimuli (e.g., approach and avoidance) under reward and punishment conditions and subsequently trained under reversed reward values (i.e., the approach which was previously rewarded is punished and vice versa).

A nondirective psychotherapy approach originated by Carl Rogers. The goals of therapy are to promote the client’s congruence, self awareness, and self acceptance. This approach views the client as naturally directed toward self actualization, and only needing facilitative conditions in order to promote this tendency.

Quick Search

DeepDyve research library

Relevant Topics

Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...

Drug Discovery
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...

Searches Linking to this Article