GC-MS Metabolite Profile and Identification of Unusual Homologous Cannabinoids in High Potency Cannabis sativa.

07:00 EST 13th February 2020 | BioPortfolio

Summary of "GC-MS Metabolite Profile and Identification of Unusual Homologous Cannabinoids in High Potency Cannabis sativa."

Phytochemical investigation of the lipids extracted from seeds of by GC-MS showed 43 cannabinoids, 16 of which are new. The extract is dominated by Δ-tetrahydrocannabinolic acid (A) and its neutral derivative -Δ-tetrahydrocannabinol-C (THC) and -Δ-tetrahydrocannabinol-C isomers with an ethyl-pentyl branched chain together with minor amounts of -Δ-tetrahydrocannabinol with a methyl-pentyl C branched side chain were identified as new natural compounds. Four cannabichromene isomers with a C side chain are postulated to be derived from the double bond migration at the terminal isoprenyl unit. C cannabichromene together with the neutral and acidic forms of cannabinol-C were also detected. The mass spectrum of these homologues as trimethylsilyl (TMS) derivatives are presented, and the fragmentation patterns are discussed.


Journal Details

This article was published in the following journal.

Name: Planta medica
ISSN: 1439-0221


DeepDyve research library

PubMed Articles [21684 Associated PubMed Articles listed on BioPortfolio]

Drug Metabolite Identification using UHPLC UV Spectroscopy and Parallelized Scans on a Tribrid Orbitrap Mass Spectrometer.

To capture all metabolites in metabolite identification studies, MS/MS information is required in both positive and negative ionisation modes, usually requiring several sample injections to gain all s...

Overview of Tandem Mass Spectral and Metabolite Databases for Metabolite Identification in Metabolomics.

Liquid chromatography-mass spectrometry (LC-MS) is one of the most popular technologies in metabolomics. The large-scale and unambiguous identification of metabolite structures remains a challenging t...

Emerging Synthetic Cannabinoids: Development and Validation of a Novel Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry Assay for Real-Time Detection.

Synthetic cannabinoids pose significant threats to public health and safety, as their implications in overdose and adverse events continue to arise in United States and around the world. Synthetic can...

5F-MDMB-PICA Metabolite Identification and Cannabinoid Receptor Activity.

According to EMCDDA, there were 179 different synthetic cannabinoids reported as of 2017. In the US, 5F-MDMB-PINACA, or 5F-ADB, accounted for 28% of cannabinoid seizures 2016-2018. The synthetic canna...

Analysis of synthetic cannabinoids on paper before and after processing for latent print using DFO and ninhydrin.

There have been several cases in the news regarding the presence of synthetic cannabinoids on paper being smuggled into jails and prisons in the United States. The Allegheny County Office of the Medic...

Clinical Trials [8358 Associated Clinical Trials listed on BioPortfolio]

Mass Balance Recovery, Metabolite Profile and Metabolite Identification of [14C]-BIA 9-1067

The purpose is to and to assess the mass balance recovery after a single oral dose of [14C]-BIA 9-1067 and to provide plasma, urine and faecal samples for metabolite profiling and structur...

A Study to Assess the Mass Balance Recovery, Metabolite Profile and Metabolite Identification of [14C]-SK-1405

The primary objectives of the study are: - To assess the mass balance recovery after a single PO dose of [14C]-SK-1405 - To provide plasma, urine and faecal samples for metabolite ...

Mass Balance Recovery, Metabolite Profile and Metabolite Identification of [14C]-MD1003 in Healthy Male Subjects

This single-center, open-label, non randomized Phase I study is being conducted to investigate the pharmacokinetics, mass balance and metabolite profiling and identification after a single...

Cannabinoids in PLWHIV on Effective ART

The purpose of this pilot study is to assess feasibility and to examine whether oral cannabinoids (capsules containing Δ9-tetrahydrocannabinol and cannabidiol in 2 different ratios) are s...

Mass-balance Study of [14C]-APD421 in Healthy Volunteers

Open-label, non-randomised, single dose study in 6 healthy male subjects to assess the mass balance recovery, metabolite profile, metabolite identification and pharmacokinetics of 14C-labe...

Medical and Biotech [MESH] Definitions

A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.

The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.

A child or adolescent who, when compared to others of the same age or experience, exhibits capability of high performance in intellectual, creative, or artistic areas, possesses an unusual capacity for leadership or excels in specific academic fields. (From PL 100-297, Sec. 4103, Definitions)

A 20 cM region of mouse chromosome 17 that is represented by a least two HAPLOTYPES. One of the haplotypes is referred to as the t-haplotype and contains an unusual array of mutations that affect embryonic development and male fertility. The t-haplotype is maintained in the gene pool by the presence of unusual features that prevent its recombination.

A MEPERIDINE congener used as an antidiarrheal, usually in combination with ATROPINE. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity.

Quick Search

DeepDyve research library

Relevant Topics

Multiple Sclerosis MS
Multiple sclerosis (MS) is the most common disabling neurological condition affecting 100,000 young adults in the UK. The condition results from autoimmune damage to myelin, causing interference in nerve signaling. Symptoms experienced depend on the pa...

Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...

Searches Linking to this Article