A pilot study: effect of erythrocyte lifespan determined by a modified carbon monoxide breath test on glycosylated hemoglobin interpretation.

07:00 EST 13th February 2020 | BioPortfolio

Summary of "A pilot study: effect of erythrocyte lifespan determined by a modified carbon monoxide breath test on glycosylated hemoglobin interpretation."

Glycosylated hemoglobin (HbA1c) is an important criterion for the diagnosis of diabetes and indicator of blood glucose level. But the red blood cell (RBC) lifespan heterogeneity is sufficient to influence on HbA1c interpretation. In this study, we recruited 115 patients with diabetes mellitus and 81 nondiabetic controls. The HbA1c and the RBC lifespan was detected by high performance liquid chromatography and the advanced CO breath detection method, respectively. Potential correlations of gender and age with HbA1c were analyzed and a receiver operator characteristic (ROC) curve was generated to get the HbA1c cut-off for every RBC lifespan group. It was confirmed that HbA1c has no correlation with gender and age. And the correlation formula between HbA1c diagnostic criteria and RBC lifespan was derived to correct the HbA1c diagnostic criteria using the least-square method. The RBC-lifespan-corrected HbA1c diagnostic criteria provided 100% sensitivity and specificity for the diagnosis of diabetes in the experimental set and was not refuted in the validated set. The diagnostic value of HbA1c is positively correlated with the RBC lifespan, and 4 patients with hyperglycemia, whose HbA1c values are lower than the general diagnosis criterion 6.5%, were still considered to be diabetic according to this formula, that is, the application of this formula may help us to eliminate 2.2% misdiagnosis rate of the current diagnostic criteria. To provide more accurate detection results, the effect of RBC lifespan is necessary to be taken into account when HbA1c is used as a clinical indicator.


Journal Details

This article was published in the following journal.

Name: Journal of breath research
ISSN: 1752-7163


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