Topics

DeepDose: towards a fast dose calculation engine for radiation therapy using deep learning.

07:00 EST 13th February 2020 | BioPortfolio

Summary of "DeepDose: towards a fast dose calculation engine for radiation therapy using deep learning."

We present DeepDose, a deep learning framework for fast dose calculations in radiation therapy. Given a patient anatomy and linear-accelerator IMRT multi-leaf-collimator shape or segment, a novel set of physics-based inputs is calculated that encode the linac machine parameters into the underlying anatomy. These inputs are then used to train a deep convolutional network to derive the dose distribution of individual MLC shapes on a given patient anatomy. In this work we demonstrate the proof-of-concept application of DeepDose on 101 prostate patients treated in our clinic with fixed-beam IMRT. The ground-truth data used for training, validation and testing of the prediction were calculated with a state-of-the-art MonteCarlo dose engine at 1% statistical uncertainty per segment. A deep convolution network was trained using the data of 80 patients at the clinically used 3 mmgrid spacing while 10 patients were used for validation. For another 11 independent test patients, the network was able to accurately estimate the segment doses from the clinical plans of each patient passing the clinical QA when compared with the MonteCarlo calculations, yielding on average 99.9%±0.3% for the forward calculated patient plans at 3%/3mm gamma tests. Dose prediction using the trained network was very fast at approximately 0.9 seconds for the input generation and 0.6 seconds for single GPU inference per segment and 1 minute per patient in total. The overall performance of this dose calculation framework in terms of both accuracy and inference speed, makes it compelling for online adaptive workflows where fast segment dose calculations are needed.

Affiliation

Journal Details

This article was published in the following journal.

Name: Physics in medicine and biology
ISSN: 1361-6560
Pages:

Links

DeepDyve research library

PubMed Articles [17153 Associated PubMed Articles listed on BioPortfolio]

Minibeam radiation therapy at a conventional irradiator: Dose-calculation engine and first tumor-bearing animals irradiation.

Minibeam radiation therapy (MBRT) is a novel therapeutic strategy, whose exploration was hindered due to its restriction to large synchrotrons. Our recent implementation of MBRT in a wide-spread small...

Patient organ and effective dose estimation in CT: comparison of four software applications.

Radiation dose in computed tomography (CT) has become a topic of high interest due to the increasing numbers of CT examinations performed worldwide. Hence, dose tracking and organ dose calculation sof...

Synchrotron microbeam radiation therapy as a new approach for treatment of radio-resistant melanoma: potential underlying mechanisms.

Synchrotron microbeam radiation-therapy (MRT) is a method that spatially distributes the X-ray beam into several microbeams of very high dose (peak-dose), regularly separated by low-dose intervals (va...

Does the Incidence of Treatment-Related Toxicity Plateau After Radiation Therapy: The Long-Term Impact of Integral Dose in Hodgkin's Lymphoma Survivors.

Conventional radiation therapy (RT) has produced unprecedented cure rates in patients with Hodgkin's lymphoma (HL) but exposed large volumes of nontargeted tissue to radiation (integral dose).

Deep DoseNet: A deep neural network for accurate dosimetric transformation between different spatial resolutions and/or different dose calculation algorithms for precision radiation therapy.

The purpose of this work is to introduce a novel deep learning strategy to obtain highly accurate dose plan by transforming from a dose distribution calculated using a low-cost algorithm (or algorithm...

Clinical Trials [13630 Associated Clinical Trials listed on BioPortfolio]

Improving Assessment (and Ultimately Outcomes) of Permanent Prostate Implant Therapy

Permanent prostate implants are a type of radiation therapy in which a high dose of radiation is delivered to cancerous tissue by many small radioactive "seeds". Studies of early-stage pr...

An Engagement Engine for Fitness Trackers

The iTrackFitness study aims to test the "engagement engine" that was developed from activity tracker and survey data gathered during phase I of the study. For the current phase the "engag...

Validation of a New Post Image Processing Engine (S-Vue™) for the Reduction of Ionizing Radiation Dose on X-ray Examination in Pediatric Patients

The purpose of this study is to compare X-ray images obtained using the standard full dose to X-ray images obtained using the Samsung S-Vue system, which allows images to be obtained using...

Stereotactic Body Radiation Therapy With Boost Using Urethral-Sparing Intensity-Modulated Radiation Therapy Planning in Treating Patients With Prostate Cancer

This phase I/II trial studies the side effects and best dose of stereotactic body radiation therapy while using intensity-modulated radiation therapy (IMRT) planning to help avoid radiatio...

Secondary Cancer Risk After Radiation Therapy for Rectal Cancer

Retrospective study comparing dose distribution of 3D conformal radiotherapy (3DCRT) and volumetric-modulated arc therapy (VMAT) to estimate secondary cancer risk for patients having had r...

Medical and Biotech [MESH] Definitions

Administration of the total dose of radiation (RADIATION DOSAGE) in parts, at timed intervals.

The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.

The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).

The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation.

A treatment schedule in which the total dose of radiation is divided into large doses.

Quick Search


DeepDyve research library

Relevant Topic

Antiretroviral therapy
Standard antiretroviral therapy (ART) consists of the combination of at least three antiretroviral (ARV) drugs to maximally suppress the HIV virus and stop the progression of HIV disease. Huge reductions have been seen in rates of death and suffering whe...


Searches Linking to this Article