Topics

Potential clinical utility of macrophage colony-stimulating factor, monocyte chemotactic protein-1 and myeloperoxidase in predicting atherosclerotic plaque instability.

07:03 LMT 1st January 0000 | BioPortfolio

Summary of "Potential clinical utility of macrophage colony-stimulating factor, monocyte chemotactic protein-1 and myeloperoxidase in predicting atherosclerotic plaque instability."

Coronary artery diseases (CAD) are the most common cause of morbidity and mortality despite significant advances in their treatment. Therefore, current research focuses on identifying at-risk individuals with vulnerable atherosclerotic plaques in coronary arteries prior to its rupture. This requires to determine specific biomarkers that can not only detect active vulnerable plaque, but also monitor the risk of its progression and rupture. Various biomolecules, from the foam cell formation to plaque rupture, are released into the blood plasma and may serve as biomarkers of atherogenesis. This review provides an up-to-date overview of some biomolecules released from activated macrophages with a focus on their potential utility for clinical practice. It is important that these biomarkers can distinguish patients with stable, inactive plaques from those with unstable, active plaques, and also predict an increased risk of acute coronary events. Special attention was focused on the selected myeloid markers of atherosclerosis and plaque instability, including macrophage colony-stimulating factor (M-CSF), monocyte chemotactic protein-1 (MCP-1), and myeloperoxidase (MPO), which are released from activated leukocytes into blood plasma. Changed plasma levels of these biomarkers can indicate an acute phase of plaque destabilization. This makes it possible not only to measure their plasma concentrations using available biochemical laboratory methods, but also to apply them in clinical practice. In addition, the discussed biomarkers could be a potential therapeutic target leading to a reduction in premature morbidity and mortality of CAD.

Affiliation

Journal Details

This article was published in the following journal.

Name: Discovery medicine
ISSN: 1944-7930
Pages: 237-245

Links

DeepDyve research library

PubMed Articles [36099 Associated PubMed Articles listed on BioPortfolio]

FLT3L and granulocyte macrophage colony-stimulating factor enhance the anti-tumor and immune effects of an HPV16 E6/E7 vaccine.

HPV16 infections promote the development and progression of cervical cancer. We investigated Fms-like Tyrosine Kinase 3 Ligand and granulocyte macrophage colony-stimulating factor as new adjuvants to ...

Granulocyte macrophage colony stimulating factor (GM-CSF), the critical intermediate of inflammation-induced fetal membrane weakening, primarily exerts its weakening effect on the choriodecidua rather than the amnion.

We have previously demonstrated two associations of PPROM, (1) inflammation/infection (modeled by tumor necrosis factor (TNF)) and (2) decidual bleeding (modeled by thrombin), both decrease fetal memb...

Who's in charge here? Macrophage colony stimulating factor and granulocyte macrophage colony stimulating factor: Competing factors in macrophage polarization.

Macrophages make up a crucial aspect of the immune system, carrying out a variety of functions ranging from clearing cellular debris to their well-recognized roles as innate immune cells. These cells ...

Intractable disseminated maculopapular eruption in a patient with granulocyte macrophage colony-stimulating factor-producing anaplastic thyroid carcinoma.

Effect of Inhibition of Colony Stimulating Factor 1 Receptor on Choroidal Neovascularization in Mice.

Neovascular age-related macular degeneration is one of the leading causes of blindness. Microglia and macrophages play critical role in choroidal neovascularization (CNV) and may therefore be potentia...

Clinical Trials [8408 Associated Clinical Trials listed on BioPortfolio]

An Open Label Phase I Study of Subcutaneously Administered Recombinant Human GM-CSF in Patients With AIDS Virus Infection and Leukopenia

To determine the safety, immunogenicity, biological activity, ad pharmacokinetics of sargramostim ( recombinant granulocyte-macrophage colony-stimulating factor; GM-CSF ) human granulocyte...

Value of Macrophage-Colony Stimulating Factor as a New Marker of Bone Lesions in Multiple Myeloma

The Primary objective of this study is to compare serum levels of Macrophage-Colony Stimulating Factor (M-CSF) in a population of patients with multiple myeloma (MM), in a population of pa...

Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) and Mobilization of Progenitor Cells in Peripheral Arterial Disease

Peripheral arterial disease is a common condition in older adults involving poor arterial circulation in the legs leading to leg pain and debility. The body's own circulating blood vessel...

A Pilot Study to Evaluate the Effects of Subcutaneously Administered Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor in Pediatric HIV-Infected Patients With Neutropenia Secondary to Azidothymidine

To assess the safety and efficacy of subcutaneous sargramostim ( granulocyte-macrophage colony-stimulating factor; GM-CSF ) in increasing and maintaining the granulocyte count in HIV-infec...

A Study of SBRT in Combination With GM-CSF for Stage IV NSCLC Patients Who Failed in Second-line Chemotherapy

The purpose of this study is to determine whether stereotactic body radiation therapy(SBRT) combined with granulocyte-macrophage colony stimulating factor(GM-CSF) is safe, effective in the...

Medical and Biotech [MESH] Definitions

A mononuclear phagocyte colony-stimulating factor (M-CSF) synthesized by mesenchymal cells. The compound stimulates the survival, proliferation, and differentiation of hematopoietic cells of the monocyte-macrophage series. M-CSF is a disulfide-bonded glycoprotein dimer with a MW of 70 kDa. It binds to a specific high affinity receptor (RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR).

Glycoproteins found in a subfraction of normal mammalian plasma and urine. They stimulate the proliferation of bone marrow cells in agar cultures and the formation of colonies of granulocytes and/or macrophages. The factors include INTERLEUKIN-3; (IL-3); GRANULOCYTE COLONY-STIMULATING FACTOR; (G-CSF); MACROPHAGE COLONY-STIMULATING FACTOR; (M-CSF); and GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; (GM-CSF).

A receptor for MACROPHAGE COLONY-STIMULATING FACTOR encoded by the c-fms proto-oncogene (GENES, FMS). It contains an intrinsic protein-tyrosine kinase activity. When activated the receptor undergoes autophosphorylation, phosphorylation of down-stream signaling molecules and rapid down-regulation.

Receptors that bind and internalize the granulocyte-macrophage stimulating factor. Their MW is believed to be 84 kD. The most mature myelomonocytic cells, specifically human neutrophils, macrophages, and eosinophils, express the highest number of affinity receptors for this growth factor.

Granulocyte-macrophage colony-stimulating factors prepared by recombinant DNA technology.

Quick Search
DeepDyve research library

Searches Linking to this Article