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Safety and efficacy of hydroxyurea and eflornithine against most blood parasites Babesia and Theileria.

07:00 EST 13th February 2020 | BioPortfolio

Summary of "Safety and efficacy of hydroxyurea and eflornithine against most blood parasites Babesia and Theileria."

The plenteous resistance to and undesirable consequences of the existing antipiroplasmic therapies have emphasized the urgent need for new chemotherapeutics and drug targets for both prophylaxis and chemotherapy. Hydroxyurea (HYD) is an antineoplastic agent with antitrypanosomal activity. Eflornithine (α-difluoro-methyl ornithine, DFMO) is the best choice therapy for the treatment of late-stage Gambian human African trypanosomiasis.

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This article was published in the following journal.

Name: PloS one
ISSN: 1932-6203
Pages: e0228996

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Medical and Biotech [MESH] Definitions

The degree to which the blood supply for BLOOD TRANSFUSIONS is free of harmful substances or infectious agents, and properly typed and crossmatched (BLOOD GROUPING AND CROSSMATCHING) to insure serological compatibility between BLOOD DONORS and recipients.

The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed)

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Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, practicability, etc., of these interventions in individual cases or series.

The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility.

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