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Indirectly Activated Treg Allow Dominant Tolerance to Murine Skin-grafts Across an MHC Class I Mismatch After a Single Donor Specific Transfusion.

07:00 EST 12th February 2020 | BioPortfolio

Summary of "Indirectly Activated Treg Allow Dominant Tolerance to Murine Skin-grafts Across an MHC Class I Mismatch After a Single Donor Specific Transfusion."

Tolerance induced in stringent animal transplant models using donor specific transfusions (DST) has previously required additional immunological manipulation. Here we demonstrate a dominant skin-allograft tolerance model induced by a single DST across an MHC Class I mismatch in an unmanipulated B6 host.

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Name: Transplantation
ISSN: 1534-6080
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Medical and Biotech [MESH] Definitions

A replication-defective strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) capable of transforming lymphoid cells and producing a rapidly progressing lymphoid leukemia after superinfection with FRIEND MURINE LEUKEMIA VIRUS; MOLONEY MURINE LEUKEMIA VIRUS; or RAUSCHER VIRUS.

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