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Dynamics of Ketamine-induced Loss and Return of Consciousness across Primate Neocortex.

07:00 EST 11th February 2020 | BioPortfolio

Summary of "Dynamics of Ketamine-induced Loss and Return of Consciousness across Primate Neocortex."

Ketamine is a noncompetitive N-methyl-D-aspartate antagonist and is known for unique electrophysiologic profiles in electroencephalography. However, the mechanisms of ketamine-induced unconsciousness are not clearly understood. The authors have investigated neuronal dynamics of ketamine-induced loss and return of consciousness and how multisensory processing is modified in the primate neocortex.

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This article was published in the following journal.

Name: Anesthesiology
ISSN: 1528-1175
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Medical and Biotech [MESH] Definitions

A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.

A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.

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Compounds capable of relieving pain without the loss of CONSCIOUSNESS.

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