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Simultaneous Determination of Dabigatran, Rivaroxaban, and Apixaban in Human Plasma by Liquid Chromatography/Tandem Mass Spectrometry.

07:00 EST 12th February 2020 | BioPortfolio

Summary of "Simultaneous Determination of Dabigatran, Rivaroxaban, and Apixaban in Human Plasma by Liquid Chromatography/Tandem Mass Spectrometry."

Pharmacokinetic studies and therapeutic drug monitoring (TDM) of anticoagulants require a simple, rapid, and reliable analytical method for monitoring plasma concentrations. The aims of the current work were to develop and validate a liquid chromatography/tandem mass spectrometry (LC-MS/MS) method for the simultaneous determination of three direct oral anticoagulants (dabigatran, rivaroxaban, and apixaban) in human plasma that is suitable for pharmacokinetic studies and routine TDM in busy hospital laboratories.

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This article was published in the following journal.

Name: Therapeutic drug monitoring
ISSN: 1536-3694
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Separation of molecules and particles by a simultaneous action of carrier liquid flow and focusing field forces (electrical, sedimentation, or thermal), without a stationary phase.

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