Quaternary Ammonium Trifluoromethoxide Salts as Stable Sources of Nucleophilic OCF.

07:00 EST 13th February 2020 | BioPortfolio

Summary of "Quaternary Ammonium Trifluoromethoxide Salts as Stable Sources of Nucleophilic OCF."

The reaction of nucleophilic tertiary amines with trifluoromethyl and pentafluoroethyl methyl ethers provides quaternary ammonium trifluoromethoxide (NROCF) and pentafluoroethoxide (NROCFCF) salts, respectively, in good yields. The new trifluoromethoxide salts disclosed herein are uniquely stable for extended periods of time in both the solid state and in solution, which complements contemporary reagents. Here we describe the preparation of a range of NROCF salts, their long-term stability, and utility in substitution reactions.


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Name: Organic letters
ISSN: 1523-7052


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Medical and Biotech [MESH] Definitions

Various salts of a quaternary ammonium oxime that reconstitute inactivated acetylcholinesterase, especially at the neuromuscular junction, and may cause neuromuscular blockade. They are used as antidotes to organophosphorus poisoning as chlorides, iodides, methanesulfonates (mesylates), or other salts.

Derivatives of ammonium compounds, NH4+ Y-, in which all four of the hydrogens bonded to nitrogen have been replaced with hydrocarbyl groups. These are distinguished from IMINES which are RN=CR2.

QUATERNARY AMMONIUM COMPOUNDS containing three methyl groups, having the general formula of (CH3)3N+R.

Quaternary ammonium compounds that consist of an ammonium cation where the central nitrogen atom is bonded to four ethyl groups.

Inorganic compounds that include a positively charged tetrahedral nitrogen (ammonium ion) as part of their structure. This class of compounds includes a broad variety of simple ammonium salts and derivatives.

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