Topics

Liquid degradable poly(trimethylene-carbonate-co-5-hydroxy-trimethylene carbonate): an injectable drug delivery vehicle for acid-sensitive drugs.

07:00 EST 13th February 2020 | BioPortfolio

Summary of "Liquid degradable poly(trimethylene-carbonate-co-5-hydroxy-trimethylene carbonate): an injectable drug delivery vehicle for acid-sensitive drugs."

Liquid injectable hydrophobic polymers have advantages as degradable drug delivery vehicles; however, polymers examined for this purpose to date form acidic degradation products that may damage acid-sensitive drugs. Herein we report on a new viscous liquid copolymer, poly(trimethylene carbonate-co-5-hydroxy-trimethylene carbonate) that degrades through intramolecular cyclization in mild alkaline environments, producing glycerol, carbon dioxide, and water-soluble trimethylene carbonate. Copolymer degradation durations from weeks to months were obtained with 5-hydroxy-trimethylene carbonate (HTMC) content of the copolymer having the greatest impact on degradation rate, with copolymers possessing higher HTMC content degrading fastest. The degradation products of the copolymers were non-cytotoxic towards 3T3 fibroblasts and RAW 264.7 macrophages. These copolymers can be injected manually through standard gauge needles and, importantly, during in vitro degradation, the microenvironmental pH within the copolymer remained near neutral. Complete and sustained release of the acid-sensitive protein vascular endothelial growth factor was achieved, with the protein remaining highly bioactive throughout the release period. These copolymers represent a promising formulation approach for local and sustained release of acid sensitive drugs.

Affiliation

Journal Details

This article was published in the following journal.

Name: Molecular pharmaceutics
ISSN: 1543-8392
Pages:

Links

DeepDyve research library

PubMed Articles [4903 Associated PubMed Articles listed on BioPortfolio]

In vivo degradation behavior of enzyme-degradable poly(trimethylene carbonate)-based biohybrid networks of varying water content.

Polymeric biohybrid networks have significant potential as supportive materials for soft connective tissue regeneration. Their success in this regard is determined by their initial mechanical properti...

A Novel OSSO-Type Chromium (III) Complex as Versatile Catalyst for Copolymerization of Carbon Dioxide with Epoxides.

A new chromium(III) complex, bearing a bis-thioether-diphenolate [OSSO]-type ligand, was found to be an efficient catalyst in the copolymerization of CO 2 and epoxides to achieve poly(propylene carbon...

Additive Manufacturing of Bioactive Poly(trimethylene carbonate)/β-tricalcium phosphate Composites for Bone Regeneration.

Implants of bioresorbable materials combined with osteoconductive calcium phosphate ceramics show promising results to replace and repair damaged bone tissue. Here we present additive manufacturing of...

Biodegradable polymer coatings on Ti6Al7Nb alloy.

The aim of the study was to determine the influence of long term exposure to Ringer's solution of biodegradable polymer coatings containing an active substance on the Ti6Al7Nb alloy substrate on the p...

Exploring poly(ethylene glycol)-poly(trimethylene carbonate) nanoparticles as carriers of hydrophobic drugs to modulate osteoblastic activity.

Current treatment options for bone-related disorders rely on a systemic administration of therapeutic agents that possess low solubility and/or intracellular bioavailability and a high pharmacokinetic...

Clinical Trials [1312 Associated Clinical Trials listed on BioPortfolio]

Outcome Study of Lanthanum Carbonate Compared With Calcium Carbonate in Hemodialysis Patients : Landmark Study

The purpose of this study is to demonstrate decrease in cardiovascular mortality and morbidity in Japanese hemodialysis patients treated with Lanthanum carbonate compared with those with C...

A Long Term Study of Lanthanum Carbonate in Patients Requiring Dialysis Who Have Ived Lanthanum Carbonate in Previous Studies Defined by the Protocol.

The purpose of this study is to assess the safety of lanthanum carbonate in patients undergoing dialysis who have received lanthanum carbonate in the previous studies and wish to continue ...

Pharmacodynamic Study of Two Lanthanum Carbonate Formulations in Healthy Adults

This study is being conducted to assess any potential differences in the absorption and excretion between two lanthanum carbonate formulations. This study is also being done to assess the ...

The Effect of Sevelamer Carbonate on Serum Trimethylamine-n-Oxide (TMAO) Level in Patients With Chronic Kidney Disease (CKD) Stage 3b-4

The aim of this study is to investigate effects of sevelamer carbonate on reducing TMAO in stage 3b-4 CKD (pre-dialysis) patients. The study will also investigate the safety and tolerabili...

Cardiovascular Safety Study of Lodenafil Carbonate in Patients With Coronaropathy During Physical Effort

The purpose of this study is to assess the safety of lodenafil carbonate in patients with coronaropathy, evaluating the response of the body facing physical effort, including both heart an...

Medical and Biotech [MESH] Definitions

A field of chemistry which pertains to chemical compounds or ions that do not contain the element carbon (with the exception of carbon dioxide and compounds containing a carbonate radical, e.g., calcium carbonate).

Protein-mineral complexes that comprise substrates needed for the normal calcium-carbonate-phosphate homeostasis. Nanobacteria was the prior name for the particles which were originally thought to be microorganisms.

Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.

A lithium salt, classified as a mood-stabilizing agent. Lithium ion alters the metabolism of BIOGENIC MONOAMINES in the CENTRAL NERVOUS SYSTEM, and affects multiple neurotransmission systems.

A group of iron-binding proteins that tightly bind two ferrate ions along with two carbonate ions. They are found in the bodily fluids of vertebrates where they act as transport and storage molecules for iron.

Quick Search


DeepDyve research library

Relevant Topics

Drug Delivery
<!--LGfEGNT2Lhm-->Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals.  <!--LGfEGNT2Lhm-->Drug delivery technologies are <!--LGfEGNT2Lhm-->patent pr...

Nutrition
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...


Searches Linking to this Article