Linker-Regulated HS Release from Aromatic Peptide Amphiphile Hydrogels.

07:00 EST 13th February 2020 | BioPortfolio

Summary of "Linker-Regulated HS Release from Aromatic Peptide Amphiphile Hydrogels."

Controlled release is an essential requirement for delivery of hydrogen sulfide (HS) because of its reactive nature, short half-life in biological fluids, and toxicity at high concentrations. In this context, HS delivery via hydrogels may be beneficial as they can deliver HS locally at the site of interest. Herein, we employed hydrogels based on aromatic peptide amphiphiles (APAs) with tunable mechanical properties to modulate the rates of HS release. The APAs contained an aromatic -aroylthiooxime (SATO) HS donor attached with a linker to a short IAVEEE hexapeptide. Linker units included carbonyl, substituted -methylenes, alkenyl, and alkyl segments with the goal of evaluating the role of linker structure on self-assembly, capacity for hydrogelation, and HS release rate. We studied each peptide by transmission electron microscopy, circular dichroism spectroscopy, and rheology, and we measured HS release rates from each gel, triggering SATO decomposition and release of HS by addition of cysteine (Cys). Using an HS-selective electrode probe as well as a turn-on fluorescent HS probe in the presence of H9C2 cardiomyocytes, we found that the rate of HS release from the hydrogels depended on the rate of Cys penetration into the nanofiber core with stiffer gels showing longer overall release.


Journal Details

This article was published in the following journal.

Name: Biomacromolecules
ISSN: 1526-4602


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Medical and Biotech [MESH] Definitions

Proteins that are involved in the peptide chain termination reaction (PEPTIDE CHAIN TERMINATION, TRANSLATIONAL) on RIBOSOMES. They include codon-specific class-I release factors, which recognize stop signals (TERMINATOR CODON) in the MESSENGER RNA; and codon-nonspecific class-II release factors.

A peptide of 36 or 37 amino acids that is derived from PROGLUCAGON and mainly produced by the INTESTINAL L CELLS. GLP-1(1-37 or 1-36) is further N-terminally truncated resulting in GLP-1(7-37) or GLP-1-(7-36) which can be amidated. These GLP-1 peptides are known to enhance glucose-dependent INSULIN release, suppress GLUCAGON release and gastric emptying, lower BLOOD GLUCOSE, and reduce food intake.

A form of antibodies (scFv) consisting of the variable regions of only the heavy and light chains, connected by a small linker peptide. They are less immunogenic than complete immunoglobulin and thus have potential therapeutic use.

A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.

A non-peptide, kappa-opioid receptor agonist which has also been found to stimulate the release of adrenocorticotropin (ADRENOCORTICOTROPIC HORMONE) via the release of hypothalamic arginine vasopressin (ARGININE VASOPRESSIN) and CORTICOTROPIN-RELEASING HORMONE. (From J Pharmacol Exp Ther 1997;280(1):416-21)

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