Tumor-Adhesive and pH-Degradable Microgels by Microfluidics and Photo-Crosslinking for Efficient Anti-Angiogenesis and Enhanced Cancer Chemotherapy.

07:00 EST 13th February 2020 | BioPortfolio

Summary of "Tumor-Adhesive and pH-Degradable Microgels by Microfluidics and Photo-Crosslinking for Efficient Anti-Angiogenesis and Enhanced Cancer Chemotherapy."

Tumor angiogenesis with the vascular network formation provides nutrition and oxygen for cancer cells, promoting the proliferation and metastasis of malignant tumors. Bevacizumab (Bev) as an efficient antiangiogenic antibody is able to normalize the tumor vasculature with better blood flow and reduced interstitial fluid pressure, allowing drugs with more uniform distribution and deeper penetration into the tumor, while it is highly difficult to realize the simultaneous delivery of Bev and anticancer drugs localized at the tumor tissue. Here we prepared tumor-adhesive and pH-degradable PVA microgels for tumor localized delivery of Bev and docetaxel (DTX), to achieve efficient anti-angiogenesis and enhanced cancer chemotherapy. PVA microgels (~200 μm) decorated with tissue-adhesive dopamine (DA) moieties were fabricated by a combination of high-throughput microfluidics technology and photo-crosslinking chemistry with a considerable co-encapsulation efficiency for Bev and DTX. PVA microgels exhibited sustained drug release at the tumoral acidic conditions as the microgel degradation, and DA moieties on the microgels facilitated Bev with long retention at the tumor tissue, highly blocking the VEGF and inhibiting the tumor angiogenesis, as compared to free Bev or no DA-decorated microgels. In addition, the antitumor activity on the 4T1-Luc breast tumor mouse model treated with Bev/DTX co-loaded microgels showed obviously superior tumor growth inhibition than other treatment groups, in which the combinational therapy efficacy of Bev and DTX mediated by the tumor-adhesive microgels was further confirmed by the immunohistochemistry (IHC) analysis. These PVA microgels with efficient anti-angiogenesis and enhanced cancer chemotherapy provide a highly potential platform to treat different malignant tumors as well as the recurrent and metastatic tumors.


Journal Details

This article was published in the following journal.

Name: Biomacromolecules
ISSN: 1526-4602


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