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Body composition is prognostic and predictive of ipilimumab activity in metastatic melanoma.

07:00 EST 13th February 2020 | BioPortfolio

Summary of "Body composition is prognostic and predictive of ipilimumab activity in metastatic melanoma."

Body composition is minimally investigated in an immunotherapy era. Specific body composition signals such as myosteatosis may reflect aspects of patients' immunology and thereby their ability to respond to immunotherapies. Ipilimumab is a key checkpoint inhibitor in metastatic melanoma. As an antibody, it may also be more accurately dosed using body composition parameters rather than weight alone. This retrospective study aimed to investigate body composition-based dosing and outcomes.

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This article was published in the following journal.

Name: Journal of cachexia, sarcopenia and muscle
ISSN: 2190-6009
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Medical and Biotech [MESH] Definitions

An anti-CTLA-4 ANTIGEN monoclonal antibody initially indicated for the treatment of certain types of metastatic MELANOMA. Its mode of actions may include blocking of CTLA-4 mediated inhibition of CYTOTOXIC T LYMPHOCYTES, allowing for more efficient destruction of target tumor cells.

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