Exercise and IGF-1 supplementation improve angiogenesis and angiogenic cytokines in a rat model of diabetes-induced neuropathy.

07:00 EST 13th February 2020 | BioPortfolio

Summary of "Exercise and IGF-1 supplementation improve angiogenesis and angiogenic cytokines in a rat model of diabetes-induced neuropathy."

What is the central question of this study? Do changes in the level of angiogenesis related mediators (VEGF-A, TSP-1 and NF-Κb) in sciatic nerve mediate diabetic neuropathy in the Streptozotocin-induced type 1 diabetic male rat? Can exercise and IGF-I treatment improve diabetes related-decreased angiogenesis in the sciatic nerve of Streptozotocin-induced type 1 diabetic male rat? What is the main finding and it's important? VEGF-A, TSP-1 and NF-Κb levels change in the sciatic nerve of diabetic rats and may mediate diabetic neuropathy. Treatment with IGF-I and exercise could increase angiogenesis in the diabetic rats by increasing VEGF-A as well as decreasing TSP-1 and NF-Κb expression in the sciatic nerve.However, combination therapy didn't show any additive effect on angiogenesis or VEGF-A, TSP-1 and NF-Κb levels in the sciatic nerve of the diabetic rats compared with eachtreatmrnt alone.


Journal Details

This article was published in the following journal.

Name: Experimental physiology
ISSN: 1469-445X


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