Significance of mast cells in Spermatogenesis, Implantation, Pregnancy, and Abortion: Crosstalk and Molecular Mechanisms.

07:00 EST 13th February 2020 | BioPortfolio

Summary of "Significance of mast cells in Spermatogenesis, Implantation, Pregnancy, and Abortion: Crosstalk and Molecular Mechanisms."

Both subsets of MCs including MC (tryptase-positive, chymase-positive) and MC (tryptase-positive, chymase-negative) are present in the testis and epididymis. Increased number of MCs, higher levels of MC- released tryptase in testis and seminal plasma of males with fertility problems and promoting sperm motility in individuals with oligozoospermia after using MC blockers, provide evidence that MCs may play a role in male infertility/subfertility disturbances. MC- released tryptase and histamine contribute to the fibrosis and may disrupt spermatogenesis. MCs not only influence the process of spermatogenesis but also have effects on the function of other testis residing cells. MC-derived histamine may influence the steroidogenesis of Leydig cells by acting through H1R and H2R receptors. Additionally, the interaction between MCs released ATP and P2X receptors expressed on the peritubular cells may induce the production of the proinflammatory mediators by peritubular cells. Further Investigations showed that MCs may be involved in the pathology of female infertility during implantation, pregnancy, and abortion. In the uterus, MC subtype is abundant in myometrium and adjacent basal layer while MC subtype is distributed in all layers. MCs in response to hormones mainly estradiol and progesterone become activated and release a wide range of mediators including histamine, VEGF, proteases, and metalloproteinases (MMPs) that have a role in different stages of pregnancy. An increasing influx of MCs to the cervix during the pregnancy occurs that helps to the physiologic cervical ripening. While MMPs degrade the extracellular matrix (ECM), VEGF modulates neovascularization and histamine influences the embryo implantation. MC-derived histamine may have a positive effect during implantation due to its participation in tissue remodeling. MC proteases including tryptase and chymase activate the precursors of MMP2 and MMP9 to mediate ECM degradation during the physiologic menstrual cycle. There is a line of evidence that MCs have a role in abortion by releasing TNF-α.


Journal Details

This article was published in the following journal.

Name: American journal of reproductive immunology (New York, N.Y. : 1989)
ISSN: 1600-0897
Pages: e13228


DeepDyve research library

PubMed Articles [19125 Associated PubMed Articles listed on BioPortfolio]

Reaction of Mast Cells in the Zone of Polypropylene Mesh Implantation.

Reaction of mast cells of adult male Wistar rats (n=15) in the zone of polypropylene mesh fixation was studied by histochemical, immunohistochemical, and traditional morphological methods on days 1, 5...

Epigenetic control of embryo-uterine crosstalk at peri-implantation.

Embryo implantation is one of the pivotal steps during mammalian pregnancy, since the quality of embryo implantation determines the outcome of ongoing pregnancy and fetal development. A large number o...

Regulatory B cells with IL-35 and IL-10 expression in a normal and abortion-prone murine pregnancy model.

Interleukin 35 is a relatively newly discovered cytokine that is produced by regulatory B cells (Bregs) and contributes to their suppressive function, which may contribute to fetal tolerance developme...

Allergic inflammation is initiated by IL-33-dependent crosstalk between mast cells and basophils.

IgE-primed mast cells in peripheral tissues, including the skin, lung, and intestine, are key initiators of allergen-triggered edema and inflammation. Particularly in severe forms of allergy, this inf...

Initiation of abortion before there is definitive ultrasound evidence of intrauterine pregnancy: A systematic review with meta-analyses.

Women are increasingly presenting for abortion at very early gestation. However, providers may be reluctant to conduct abortion at this stage as they may be concerned that they cannot exclude an ectop...

Clinical Trials [12772 Associated Clinical Trials listed on BioPortfolio]

Embryotransfer Operator and Pregnancy Rate

Several studies had analyzed the correlation between embryo transfer operator experience and implantation, clinical pregnancy, abortion and delivery rate. The aim of the present study is ...

Quickstart of Nexplanon® at Medical Abortion

Women having abortions are at high risk for subsequent unintended pregnancy and repeat abortion. Clearly, encouraging contraceptive use after abortion is a high priority. Long acting rever...

The Effects of Lymphocyte Therapy on Pregnancy Rate of Patient With Recurrent Implantation Failure

Infertility and miscarriage ordinary events in reproductive failure in humans, as are affected one couple in every six couples of reproductive age and abortion is including in approximatel...

Simplifying First Trimester Medical Abortion Follow-up

This study evaluates the usability of the multilevel pregnancy test among women undergoing medical abortion.

Evening Primrose Oil to Misoprostol During Induction of Second-trimester Missed Miscarriage

Termination of pregnancy is an important subject that has complex and emotional controversies. The most common time of termination of pregnancy is the mid-trimester which has two-thirds of...

Medical and Biotech [MESH] Definitions

Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.

Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; SPONTANEOUS ABORTION; INDUCED ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO.

MULTIPLE PREGNANCY with EMBRYO IMPLANTATION occuring at different locations, involving both an intrauterine site and an extrauterine (ECTOPIC PREGNANCY) site.

Pregnancy in which the mother and/or FETUS are at greater than normal risk of MORBIDITY or MORTALITY. Causes include inadequate PRENATAL CARE, previous obstetrical history (ABORTION, SPONTANEOUS), pre-existing maternal disease, pregnancy-induced disease (GESTATIONAL HYPERTENSION), and MULTIPLE PREGNANCY, as well as advanced maternal age above 35.

A type of pregnancy in which EMBRYO IMPLANTATION occurs in an OVARY instead of in the uterine cavity.

Quick Search

DeepDyve research library

Relevant Topics

Women's Health
Women's Health - key topics include breast cancer, pregnancy, menopause, stroke Follow and track Women's Health News on BioPortfolio: Women's Health News RSS Women'...

Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells.  In vertebrates, it is composed of blo...

Fertility is the ability of a couple to conceive, but can related to specifically the man or woman. Various reasons can cause a couple to be infertile, and due to the strong desire of these patients to have <!--LGfEGNT2Lhm-->children, a range of ...

Searches Linking to this Article