Proteomic Level Changes on Treatment in MCF-7/DDP Breast Cancer Drug-Resistant Cells.

07:00 EST 12th February 2020 | BioPortfolio

Summary of "Proteomic Level Changes on Treatment in MCF-7/DDP Breast Cancer Drug-Resistant Cells."

LCL161, a Smac's small molecule mimetic, can bind to a variety of IAPs and activate Caspases. We found that, on its own, LCL161induces apoptosis of drug-resistant breast cancer cells by binding to a variety of IAPs and activating Caspases. However, when LCL161 is used in combination with Caspase Inhibitors (CI), its capacity induce apoptosis of breast cancer cells is enhanced.


Journal Details

This article was published in the following journal.

Name: Anti-cancer agents in medicinal chemistry
ISSN: 1875-5992


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