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Syntheses of Epoxyguaiane Sesquiterpenes (-)-Englerin A, (-)-Oxyphyllol, (+)-Orientalol E, and (+)-Orientalol F: A Synthetic Biology Approach.

07:00 EST 13th February 2020 | BioPortfolio

Summary of "Syntheses of Epoxyguaiane Sesquiterpenes (-)-Englerin A, (-)-Oxyphyllol, (+)-Orientalol E, and (+)-Orientalol F: A Synthetic Biology Approach."

A combined approach toward syntheses of epoxyguaiane sesquiterpenes is presented. By use of a fungus sesquiterpene cyclase, guaian-6,10(14)-diene was produced through metabolic engineering of the isoprenoid pathway in . (-)-Englerin A, (-)-oxyphyllol, (+)-orientatol E, and (+)-orientalol F have been synthesized in two to six steps. This strategy provided rapid access to the epoxyguaiane core structure and would facilitate syntheses of (-)-englerin A and its analogues for evaluation of their therapeutic potentials in drug discovery.

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Name: Organic letters
ISSN: 1523-7052
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Medical and Biotech [MESH] Definitions

SESQUITERPENES cyclized to one 10-carbon ring.

SESQUITERPENES cyclized into two adjoining cyclohexane rings but with a different configuration from the ARTEMISININS.

SESQUITERPENES cyclized into two adjoining rings, one being 7-carbons and the other is 5-carbons.

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