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CEAP clinical classes C0S-C4: differences, similarities and place of Ruscus+HMC+VitC in treating patients with chronic venous disease.

07:00 EST 12th February 2020 | BioPortfolio

Summary of "CEAP clinical classes C0S-C4: differences, similarities and place of Ruscus+HMC+VitC in treating patients with chronic venous disease."

Since the publication of the CEAP classification, new research has enriched our knowledge; notably on the heritability of CVD and the genetic and environmental factors involved in this condition, as well as the symptoms apparent within the spectrum of the CEAP clinical classes and the benefits of medical treatment. Using the CEAP classification as a special theme, a symposium entitled "CEAP Clinical Classes C0S-C4: Differences, Similarities and Place of Ruscus+HMC+VitC in Treating Patients with CVD" was held at the annual meeting of the 2019 European Venous Forum. The lectures presented much valuable information, from which some key points can be extracted. The influence of environmental factors was demonstrated, and the fact that a large amount of information can be obtained from comprehensive history taking. There is robust evidence for heritability. Many candidate genes/loci have been identified, potentially offering new targets for treatment. More research is needed, notably using genome-wide association studies and also on microbiota, which may play a role in CVD through the inflammation pathway. Ruscus+HMC+VitC acts by increasing venous and lymphatic tone, protecting microcirculation, and reducing inflammation. It improves quality of life in C0S to C3 CVD patients, while a review of clinical studies and a meta-analysis have confirmed its clinical efficacy across a wide spectrum of CVD clinical classes: C0S, C1S, C2, C3 and C4. It has been awarded a Grade 1A recommendation by the international guidelines.

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This article was published in the following journal.

Name: International angiology : a journal of the International Union of Angiology
ISSN: 1827-1839
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