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Building related health effects are frequently observed. Several factors have been listed as possible causes including temperature, humidity, light conditions, presence of particulate matter and microorganisms or volatile organic compounds. To be able to link exposure to specific volatile organic compounds to building related health effects powerful and comprehensive analytical methods are required. For this purpose, we developed an active air sampling method that utilizes dual-bed tubes loaded with TENAX-TA and Carboxen-1000 adsorbents to sample two parallel air samples of 4-L each. For the comprehensive volatile organic compounds analysis, an automated thermal desorption comprehensive two-dimensional gas chromatography high resolution time-of-flight mass spectrometry method was developed and used. It allowed targeted analysis of approximately 90 known volatile organic compounds with relative standard deviations below 25 % for the vast majority of target volatile organic compounds. It also allowed semi-quantification (no matching standards) of numerous non-target air contaminants, using the same data set. The non-target analysis workflow included peak finding, background elimination, feature alignment, detection frequency filtering and tentative identification. Application of the workflow to air samples from 68 indoor environments at a large hospital complex resulted in a comprehensive volatile organic compound characterization, including 178 single compounds and 13 hydrocarbon groups. This article is protected by copyright. All rights reserved.
This article was published in the following journal.
Name: Journal of separation science
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Volatile organic compounds (VOCs) are low molecular weight (
The Lung Cancer Indicator Detection (LuCID) study investigates the the diagnostic accuracy of FAIMS for diagnosis of lung cancer by analysis of exhaled Volatile Organic Compounds.
Cross sectional case-control study investigating the difference of volatile organic compound in the exhaled breath of the patients with GI bleeding and normal population.
The purpose of this secondary analysis is to identify breath signatures associated with idiopathic malodor conditions.
Organic compounds that have a relatively high VAPOR PRESSURE at room temperature.
The contamination of indoor air.
Organic compounds containing the nitroso (-N=O) group attached to an organic moiety.
Differential thermal analysis in which the sample compartment of the apparatus is a differential calorimeter, allowing an exact measure of the heat of transition independent of the specific heat, thermal conductivity, and other variables of the sample.
Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.
Multiple Sclerosis MS
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