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Analysis of volatile organic compounds in indoor environments using thermal desorption with comprehensive two-dimensional GC and high-resolution time-of-flight MS.

07:00 EST 13th February 2020 | BioPortfolio

Summary of "Analysis of volatile organic compounds in indoor environments using thermal desorption with comprehensive two-dimensional GC and high-resolution time-of-flight MS."

Building related health effects are frequently observed. Several factors have been listed as possible causes including temperature, humidity, light conditions, presence of particulate matter and microorganisms or volatile organic compounds. To be able to link exposure to specific volatile organic compounds to building related health effects powerful and comprehensive analytical methods are required. For this purpose, we developed an active air sampling method that utilizes dual-bed tubes loaded with TENAX-TA and Carboxen-1000 adsorbents to sample two parallel air samples of 4-L each. For the comprehensive volatile organic compounds analysis, an automated thermal desorption comprehensive two-dimensional gas chromatography high resolution time-of-flight mass spectrometry method was developed and used. It allowed targeted analysis of approximately 90 known volatile organic compounds with relative standard deviations below 25 % for the vast majority of target volatile organic compounds. It also allowed semi-quantification (no matching standards) of numerous non-target air contaminants, using the same data set. The non-target analysis workflow included peak finding, background elimination, feature alignment, detection frequency filtering and tentative identification. Application of the workflow to air samples from 68 indoor environments at a large hospital complex resulted in a comprehensive volatile organic compound characterization, including 178 single compounds and 13 hydrocarbon groups. This article is protected by copyright. All rights reserved.

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This article was published in the following journal.

Name: Journal of separation science
ISSN: 1615-9314
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Medical and Biotech [MESH] Definitions

Organic compounds that have a relatively high VAPOR PRESSURE at room temperature.

The contamination of indoor air.

Organic compounds containing the nitroso (-N=O) group attached to an organic moiety.

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Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.

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