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Tailored Palladium Catalysts for Selective Synthesis of Conjugated Enynes via Monocarbonylation of 1,3-Diynes.

07:00 EST 13th February 2020 | BioPortfolio

Summary of "Tailored Palladium Catalysts for Selective Synthesis of Conjugated Enynes via Monocarbonylation of 1,3-Diynes."

For the first time, the monoalkoxycarbonylation of easily available 1,3-diynes to give synthetically useful conjugated enynes has been realized. Key to success was the design and utilization of the new ligand 2,2'-bis( tert -butyl(pyridin-2-yl)phosphanyl)-1,1'-binaphthalene ( L12 , Neolephos), which permits the palladium-catalyzed selective carbonylation under mild conditions, providing a general preparation of functionalized 1,3-enynes in good to high yields with excellent chemoselectivities. Synthetic applications, which showcase the possibilities of this novel methodology include an efficient one-pot synthesis of 4-aryl-4 H -Pyrans as well as the rapid construction of various heterocyclic, bicyclic, polycyclic compounds.

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Name: Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
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