Track topics on Twitter Track topics that are important to you
For the first time, the monoalkoxycarbonylation of easily available 1,3-diynes to give synthetically useful conjugated enynes has been realized. Key to success was the design and utilization of the new ligand 2,2'-bis( tert -butyl(pyridin-2-yl)phosphanyl)-1,1'-binaphthalene ( L12 , Neolephos), which permits the palladium-catalyzed selective carbonylation under mild conditions, providing a general preparation of functionalized 1,3-enynes in good to high yields with excellent chemoselectivities. Synthetic applications, which showcase the possibilities of this novel methodology include an efficient one-pot synthesis of 4-aryl-4 H -Pyrans as well as the rapid construction of various heterocyclic, bicyclic, polycyclic compounds.
This article was published in the following journal.
Name: Angewandte Chemie (International ed. in English)
A novel Pd(II)-catalyzed reductive asymmetric cyclization of -tosyl-tethered 1,7-enynes using ethanol as a hydrogen source is reported. This reaction provides facile ways for the synthesis of two type...
Catalytic asymmetric and divergent assembly of tricyclic and tetracyclic 3,3'-pyrrolidonyl spirooxindoles was developed, involving a one-pot chiral Brønsted base catalyzed asymmetric propargylation f...
A cooperative Cu/Pd-catalyzed enantioselective synthesis of multisubstituted allenes is established. By employing chiral sulfoxide phosphine (SOP)/Cu and PdCl (dppf) complexes as catalysts, the 1,4-ar...
We report selective removals of N-terminal and internal Cys protecting groups using different palladium complexes to facilitate the efficient chemical protein synthesis. Utilizing the orthogonal depro...
A new strategy for the synthesis of conjugated (E,E)-dienones and (E,E)-dienals via a palladium-catalyzed aerobic γ,δ-dehydrogenation of enones and enals has been developed. The method can be employ...
Vulvovaginal atrophy (VVA) is a condition that impacts up to 60% of the growing postmenopausal female population, and the most common symptom is dyspareunia. Vaginal estrogen is the most c...
The purpose of this research study is to evaluate the safety and effectiveness of this investigational drug for the treatment of menopausal symptoms while protecting the endometrium (uteri...
The primary purpose is to determine bioavailability of Bazedoxifene/conjugated estrogen formulations for future testing purposes.
The purpose of this study is to determine whether Bazedoxifine/conjugated estrogens are effective in the treatment of vaginal atrophy.
The purpose of this study is to determine whether bazedoxifene/conjugated estrogens combinations are effective in the treatment of moderate to severe vasomotor symptoms associated with men...
The fusion of ceramics (porcelain) to an alloy of two or more metals for use in restorative and prosthodontic dentistry. Examples of metal alloys employed include cobalt-chromium, gold-palladium, gold-platinum-palladium, and nickel-based alloys.
An RNA polymerase II transcriptional inhibitor. This compound terminates transcription prematurely by selective inhibition of RNA synthesis. It is used in research to study underlying mechanisms of cellular regulation.
A collective term for a group of around nine geometric and positional isomers of LINOLEIC ACID in which the trans/cis double bonds are conjugated, where double bonds alternate with single bonds.
Biological catalysts and their cofactors.
The facilitation of biochemical reactions with the aid of naturally occurring catalysts such as ENZYMES.