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The two most common types of ERP-based protocols to detect concealed information are the 3-stimulus protocol (3SP) and Complex Trial Protocol (CTP). Both protocols traditionally include presentation of a target (a stimulus with assigned significance requiring a unique behavioral response). The intention of the target presentation is forcing subjects to pay attention to all stimuli, especially to guilty knowledge stimuli, called probes. It was unclear though, how the presence of a targets influences probe recognition, and thus, the concealed information test (CIT) effect-the difference in P300 response to the probe and Irrelevant (crime-unrelated) stimuli. The question of target necessity was first raised in relation to the 3SP, and it was found that although omitting target stimuli reduced P300 amplitudes for all probe and irrelevant stimuli, the CIT effect was not reduced. The current study investigated how the presence or absence of the target/nontarget discrimination in the CTP affects the CIT effect, by comparing two CTP groups both with (T) and without (NT) the target/nontarget discrimination. The results demonstrated that this discrimination significantly increases the P300 effect. We found a greater P300 CIT effect in the T group than in the NT group, suggesting that for field use, it is better to retain the target discrimination in the CTP. CIT effects were also seen with P300 latency, but not reaction time.
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Administration of the microtubule inhibitor docetaxel is a common treatment for metastatic castration-resistant prostate cancer (mCRPC) and results in prolonged patient overall survival. Usually, afte...
The impact of reduced adherence in randomized clinical trials is well documented in the literature. Nonadherence can negatively affect the trial sample size and estimation of the treatment effect. Thi...
Correction to: Does a Screening Trial for Spinal Cord Stimulation in Patients with Chronic Pain of Neuropathic Origin have Clinical Utility and Cost-Effectiveness? (TRIAL-STIM Study): study protocol for a randomised controlled trial.
Following publication of the original article , we have been notified that the final specification of randomisation implemented in the study is slightly different to that stated in the protocol and...
p300 is an important histone acetyltransferase in epigenetics, and its overexpression is closely related to various diseases such as cancers. C646 is one of the most representative p300 inhibitors and...
Tactile brain-computer interface (BCI) systems can provide new communication and control options for patients with impairments of eye movements or vision. One of the most common modalities used in the...
Patients with Amyotrophic Lateral Sclerosis (ALS) will use a P300 based brain computer interface (BCI) keyboard to type in assistive technology devices. The results of this study will be ...
This is a controlled trial designed to determine short- and long-term effects of repeated tDCS on the P300 component of event-related evoked potentials in patients with chronic neuropathi...
Due to a number of factors, including power differentials and adverse events, residents are susceptible to mistreatment (i.e., discrimination, harassment, and abuse) and toxic outcomes (i....
Bilateral severe to profound hearing loss is a socially disabling handicap. Cochlear implants can be used to improve hearing in cases where conventional hearing aids are not effective. The...
This study is designed to investigate whether IVUS-guided DK crush stenting technique compared to angiography-guided DK crush after the indexed procedure will lead to lower rates of the co...
Clinical study in which a prospectively planned opportunity is included to modify trial designs and hypotheses based on analysis of data from subjects in the study.
A member of the p300-CBP transcription factors that was originally identified as a binding partner for ADENOVIRUS E1A PROTEINS.
Prejudice or discrimination based on gender or behavior or attitudes that foster stereotyped social roles based on gender.
Legal guarantee protecting the individual from attack on personal liberties, right to fair trial, right to vote, and freedom from discrimination on the basis of race, color, religion, sex, age, disability, or national origin. (from http://www.usccr.gov/ accessed 1/31/2003)
A late-appearing component of the event-related potential. P300 stands for a positive deflection in the event-related voltage potential at 300 millisecond poststimulus. Its amplitude increases with unpredictable, unlikely, or highly significant stimuli and thereby constitutes an index of mental activity. (From Campbell, Psychiatric Dictionary, 6th ed)