The Effect of PDE5 Inhibitors on the Male Reproductive Tract.

07:00 EST 26th February 2020 | BioPortfolio

Summary of "The Effect of PDE5 Inhibitors on the Male Reproductive Tract."

The therapeutic range of cyclic nucleotide phosphodiesterase 5 inhibitors (PDE5) inhibitors is getting wider in the last years. This review study focuses on the potential employment of PDE5 inhibitors as an adjunct tool for the therapeutic management of male infertility. The literature tends to suggest a beneficial effect of PDE5 inhibitors on Leydig and Sertoli cells secretory function. It also appears that PDE5 inhibitors play a role in the regulation of the contractility of the testicular tunica albuginea and the epididymis. Moreover scientific data suggest that PDE5 inhibitors enhance the prostatic secretory function leading to an improvement in sperm motility. Other studies additionally demonstrate a role of PDE5 inhibitors in the regulation of sperm capacitation process. Placebo-controlled, randomized, blind studies are necessary to unambiguously incorporate PDE5 inhibitors as an adjunct tool for the pharmaceutical treatment of semen disorders and male infertility.


Journal Details

This article was published in the following journal.

Name: Current pharmaceutical design
ISSN: 1873-4286


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Medical and Biotech [MESH] Definitions

Passive or active movement of SPERMATOZOA from the testicular SEMINIFEROUS TUBULES through the male reproductive tract as well as within the female reproductive tract.

MYCOBACTERIUM infections of the male reproductive tract (GENITALIA, MALE).

Pathological processes involving the male reproductive tract (GENITALIA, MALE).

Pathological processes of the male URINARY TRACT and the reproductive system (GENITALIA, MALE).

A scientific or medical discipline concerning the study of male reproductive biology, diseases of the male genital organs, and male infertility. Major areas of interest include ENDOCRINOLOGY; SPERMATOGENESIS; semen analysis; FERTILIZATION; CONTRACEPTION; and CRYOPRESERVATION.

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