Topics

The Effect of PDE5 Inhibitors on the Male Reproductive Tract.

07:00 EST 26th February 2020 | BioPortfolio

Summary of "The Effect of PDE5 Inhibitors on the Male Reproductive Tract."

The therapeutic range of cyclic nucleotide phosphodiesterase 5 inhibitors (PDE5) inhibitors is getting wider in the last years. This review study focuses on the potential employment of PDE5 inhibitors as an adjunct tool for the therapeutic management of male infertility. The literature tends to suggest a beneficial effect of PDE5 inhibitors on Leydig and Sertoli cells secretory function. It also appears that PDE5 inhibitors play a role in the regulation of the contractility of the testicular tunica albuginea and the epididymis. Moreover scientific data suggest that PDE5 inhibitors enhance the prostatic secretory function leading to an improvement in sperm motility. Other studies additionally demonstrate a role of PDE5 inhibitors in the regulation of sperm capacitation process. Placebo-controlled, randomized, blind studies are necessary to unambiguously incorporate PDE5 inhibitors as an adjunct tool for the pharmaceutical treatment of semen disorders and male infertility.

Affiliation

Journal Details

This article was published in the following journal.

Name: Current pharmaceutical design
ISSN: 1873-4286
Pages:

Links

DeepDyve research library

PubMed Articles [19349 Associated PubMed Articles listed on BioPortfolio]

Phosphodiesterase 5 inhibitors as novel agents for the treatment of Alzheimer's disease.

Alzheimer's disease (AD), characterized by a progressive impairment of memory and cognition, is a major health problem in both developing and developed countries. Currently, no drugs can reverse the p...

Aquaporins and male (in)fertility: Expression and role throughout the male reproductive tract.

Aquaporins (AQPs) are a family of transmembrane channel proteins responsible for the transport of water and small uncharged molecules. Thirteen distinct isoforms of AQPs have been identified in mammal...

Effect of antidepressant medications on semen parameters and male fertility.

Antidepressant medications are commonly used in males of reproductive age for long-term treatment of depression, as well as other disorders. Although antidepressants are known to be associated with se...

Low-dose PDE5 inhibitors for erectile dysfunction with subclinical metabolic syndrome.

To investigate the effects of low-dose PDE5 inhibitors on metabolic parameters and erectile function in ED patients with subclinical metabolic syndrome (SCMS).

PDE5 inhibitors as a medicinal guide drug in the treatment of erectile dysfunction.

Medicinal guide theory is a unique theory of Chinese medicine, which bears some similarities to the modern targeted drug delivery system. Modern pharmacological studies have revealed some scientific c...

Clinical Trials [7989 Associated Clinical Trials listed on BioPortfolio]

Effect of Reproductive Tract Microbiota on Pregnancy Outcome in IVF/ICSI

A single center,observational cohort study to explore the relationship between reproductive tract microbiota and pregnancy outcome in the patients accepted IVF/ICSI. To investigate wheth...

A Study to Determine if There is a Possible Association Between Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) and Phosphodiesterase Type 5 (PDE5) Inhibitors

Study H6D-MC-LVHQ is an observational, non-interventional, multi-center, prospective, case-crossover study to evaluate the possible association between the use of phosphodiesterase type 5 ...

Stress Management Using an App to Improve Response With PDE5 Inhibitors in Men With Erectile Dysfunction.

The aim of this study is to determine if patients with ED taking PDE5 inhibitors (e.g. Viagra, CIalis, Levitra, Stendra) and experiencing performance anxiety will benefit using a user-frie...

Serum and Semen Vitamin D Level With Semen Parameters

vitamin D may have multiple functions, one of them is modulating reproductive processes and the reproductive role of vitamin D is highlighted by expression of the vitamin D receptors in te...

PDE5 Inhibitor Use and Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)

The primary objective of this study is to determine whether the use of PDE5 inhibitors (vardenafil, sildenafil, or tadalafil) increases the risk for the development of NAION

Medical and Biotech [MESH] Definitions

Passive or active movement of SPERMATOZOA from the testicular SEMINIFEROUS TUBULES through the male reproductive tract as well as within the female reproductive tract.

MYCOBACTERIUM infections of the male reproductive tract (GENITALIA, MALE).

Pathological processes involving the male reproductive tract (GENITALIA, MALE).

Pathological processes of the male URINARY TRACT and the reproductive system (GENITALIA, MALE).

A scientific or medical discipline concerning the study of male reproductive biology, diseases of the male genital organs, and male infertility. Major areas of interest include ENDOCRINOLOGY; SPERMATOGENESIS; semen analysis; FERTILIZATION; CONTRACEPTION; and CRYOPRESERVATION.

Quick Search


DeepDyve research library

Relevant Topic

Prostate Cancer
Prostate cancer (cancer de prostata) Prostate cancer (cancer de prostata) is a form of cancer that develops in the prostate, a gland in the male reproductive system. Most prostate cancers are slow growing; however, there are cases of aggressive prostat...


Searches Linking to this Article