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Recognising the signals for endosomal trafficking.

07:00 EST 7th March 2020 | BioPortfolio

Summary of "Recognising the signals for endosomal trafficking."

The endosomal compartment is a major sorting station controlling the balance between endocytic recycling and lysosomal degradation, and its homeostasis is emerging as a central factor in various neurodegenerative diseases such as Alzheimer's and Parkinson's. Membrane trafficking is generally coordinated by the recognition of specific signals in transmembrane protein cargos by different transport machineries. A number of different protein trafficking complexes are essential for sequence-specific recognition and retrieval of endosomal cargos, recycling them to other compartments and acting to counter-balance the default endosomal sorting complex required for transport-mediated degradation pathway. In this review, we provide a summary of the key endosomal transport machineries, and the molecular mechanisms by which different cargo sequences are specifically recognised.

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This article was published in the following journal.

Name: Current opinion in cell biology
ISSN: 1879-0410
Pages: 17-27

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Medical and Biotech [MESH] Definitions

Protein sorting signals that target proteins to PEROXISOMES.

The process in which light signals are transformed by the PHOTORECEPTOR CELLS into electrical signals which can then be transmitted to the brain.

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