Recognising the signals for endosomal trafficking.

07:00 EST 7th March 2020 | BioPortfolio

Summary of "Recognising the signals for endosomal trafficking."

The endosomal compartment is a major sorting station controlling the balance between endocytic recycling and lysosomal degradation, and its homeostasis is emerging as a central factor in various neurodegenerative diseases such as Alzheimer's and Parkinson's. Membrane trafficking is generally coordinated by the recognition of specific signals in transmembrane protein cargos by different transport machineries. A number of different protein trafficking complexes are essential for sequence-specific recognition and retrieval of endosomal cargos, recycling them to other compartments and acting to counter-balance the default endosomal sorting complex required for transport-mediated degradation pathway. In this review, we provide a summary of the key endosomal transport machineries, and the molecular mechanisms by which different cargo sequences are specifically recognised.


Journal Details

This article was published in the following journal.

Name: Current opinion in cell biology
ISSN: 1879-0410
Pages: 17-27


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