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This review aimed to provide an overview of the level of maturity of normal tissue complication probability (NTCP) models for head and neck cancer (HNC) patients. A systematic literature review was performed to retrieve NTCP models for HNC toxicities. Patient population characteristics, NTCP model and the predictors, treatment technique and endpoint definition were extracted per article. Models were then scored based on the TRIPOD (transparent reporting of a multivariable prediction model for individual prognosis or diagnosis) consensus guidelines to evaluate their generalizability. 335 articles on photon and proton therapy of HNC were identified and 52 relevant articles were further analyzed. Eighteen articles on xerostomia and sticky saliva (TRIPOD types 1a-2b: 15; TRIPOD type 3: 1; TRIPOD types 4a: 1 & 4b:1), thirteen articles on dysphagia and tube feeding dependence (TRIPOD types 1a-2b: 7; TRIPOD type 3: 2; TRIPOD types 4a:2 & 4b:2), five articles on oral mucositis (TRIPOD types 1a-2b: 4; TRIPOD type 4b: 1), seven articles on hypothyroidism (TRIPOD types 1a-2b: 4; TRIPOD type 3: 1; TRIPOD types 4a: 1 & 4b:1), four articles on hearing loss and tinnitus (TRIPOD type 1a: 4) and ten articles on esophagitis (TRIPOD types 1a-2b: 9; TRIPOD type 4a: 1) were included. External validation studies of HNC NTCP models are scarce. Moreover, the majority of them were validating a model developed by the same researchers. Only 2 independent external validation studies were found. There is a strong need to publish external validation studies to get more mature NTCP models applicable in clinical practice.
This article was published in the following journal.
Name: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
To evaluate pix2pix and CycleGAN and to assess the effects of multiple combination strategies on accuracy for patch-based synthetic CT (sCT) generation for MR-only treatment planning in head and neck ...
Chronic rhinosinusitis (CRS) is a common post-radiotherapy (RT) side effect in patients with nasopharyngeal cancer (NPC). However, whether RT is a risk factor for CRS in patients with other types of h...
Although neck impairment has been described following surgical resection, limited studies have investigated its prevalence in nonsurgical treatment. The purpose of this study is to determine the preva...
The aim of the study was to assess the feasibility of multi tracer PET imaging before and during chemoradiation and to evaluate the predictive value of image-based factors for outcome in locally advan...
Improved head and neck cancer survival has been associated with traveling farther distances for treatment, potentially due to patients seeking higher-quality facilities. This study investigates the ro...
Background of the study: Swallowing dysfunction and xerostomia are the most frequently reported radiation-induced side effects (RISE) after (chemo) radiation ((CH) RT) in head and neck ca...
This is an multicenter study for preventive and therapeutic strategies for patients with head and neck cancer
A prospective real world evidence study of Nivolumab use in France in patient with recurrent or metastatic squamous cell carcinoma of the Head and Neck progressing on or after a platinum b...
The purpose of this study is to determine whether TAS-106 is effective to patients with recurrent or metastatic head and neck cancer refractory to platinum based chemotherapy.
Through this study, we hope to learn more about the mechanisms, which may contribute to development and progression of head and neck cancer. The long-term goal of this study will be to de...
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Dissection in the neck to remove all disease tissues including cervical LYMPH NODES and to leave an adequate margin of normal tissue. This type of surgery is usually used in tumors or cervical metastases in the head and neck. The prototype of neck dissection is the radical neck dissection described by Crile in 1906.
Theoretical models simulating behavior or activities in nursing, including nursing care, management and economics, theory, assessment, research, and education. Some examples of these models include Orem Self-Care Model, Roy Adaptation Model, and Rogers Life Process Model.
A form of RHABDOMYOSARCOMA arising primarily in the head and neck, especially the orbit, of children below the age of 10. The cells are smaller than those of other rhabdomyosarcomas and are of two basic cell types: spindle cells and round cells. This cancer is highly sensitive to chemotherapy and has a high cure rate with multi-modality therapy. (From Holland et al., Cancer Medicine, 3d ed, p2188)
A diverse superfamily of proteins that function as translocating proteins. They share the common characteristics of being able to bind ACTINS and hydrolyze MgATP. Myosins generally consist of heavy chains which are involved in locomotion, and light chains which are involved in regulation. Within the structure of myosin heavy chain are three domains: the head, the neck and the tail. The head region of the heavy chain contains the actin binding domain and MgATPase domain which provides energy for locomotion. The neck region is involved in binding the light-chains. The tail region provides the anchoring point that maintains the position of the heavy chain. The superfamily of myosins is organized into structural classes based upon the type and arrangement of the subunits they contain.
Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma Leukemia Lung Cancer Melanoma Myeloma Ovarian Cancer Pancreatic Cancer ...
The thyroid is a butterfly-shaped gland in the neck, just above thecollarbone and is an endocrine gland that make hormones. These Thyroid hormones control the rate of many activities in the body, including how fast the body burns calories and how fast th...